Small nuclear ribonucleoprotein polypeptide E

SNRPE

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR

Identifiers

SNRPE, B-raf, HYPT11, SME, Sm-E, Small nuclear ribonucleoprotein polypeptide E, snRNP-E

External IDs

OMIM: 128260; MGI: 3650419; HomoloGene: 136765; GeneCards: SNRPE; OMA:SNRPE - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q32.1	Start	203,861,599 bp^[1]
Band	1q32.1	End	203,871,152 bp^[1]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

ventricular zone

left ovary

right ovary

olfactory zone of nasal mucosa

body of pancreas

canal of the cervix

ectocervix

body of uterus

mucosa of transverse colon

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding RNA binding
Cellular component	cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U12-type spliceosomal complex nucleoplasm methylosome U7 snRNP small nuclear ribonucleoprotein complex pICln-Sm protein complex telomerase holoenzyme complex spliceosomal complex U4 snRNP nucleus U5 snRNP U2 snRNP U4/U6 x U5 tri-snRNP complex precatalytic spliceosome U1 snRNP U2-type catalytic step 2 spliceosome U2-type precatalytic spliceosome
Biological process	hair cycle mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly histone mRNA metabolic process import into nucleus RNA splicing
Sources:Amigo / QuickGO

Species

Human

Mouse


6635


102632439


ENSG00000182004


n/a


P62304


n/a

RefSeq (mRNA)


NM_001304464 NM_003094 NM_001328637 NM_001328638


n/a

RefSeq (protein)


NP_001291393 NP_001315566 NP_001315567 NP_003085


n/a

Location (UCSC)

Chr 1: 203.86 – 203.87 Mb

n/a

PubMed search

^[2]

^[3]

View/Edit Human

View/Edit Mouse

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.^[4]^[5]^[6]

Interactions

Small nuclear ribonucleoprotein polypeptide E has been shown to interact with DDX20^[7] and Small nuclear ribonucleoprotein polypeptide F.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fautsch MP, Wieben ED (December 1991). "Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins". The Journal of Biological Chemistry. 266 (34): 23288–95. doi:10.1016/S0021-9258(18)54495-1. PMID 1835977.
^ Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I, Heinzmann C, Wieben ED (August 1990). "Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43". Genomics. 7 (4): 503–8. doi:10.1016/0888-7543(90)90192-W. PMID 2143747.
^ "Entrez Gene: SNRPE small nuclear ribonucleoprotein polypeptide E".
^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
^ Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.

Further reading

Sauterer RA, Goyal A, Zieve GW (January 1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". The Journal of Biological Chemistry. 265 (2): 1048–58. doi:10.1016/S0021-9258(19)40157-9. PMID 1688550.
Stanford DR, Rohleder A, Neiswanger K, Wieben ED (July 1987). "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene". The Journal of Biological Chemistry. 262 (21): 9931–4. doi:10.1016/S0021-9258(18)61052-X. PMID 2440864.
Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (April 1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". The Journal of Biological Chemistry. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
Stanford DR, Perry CA, Holicky EL, Rohleder AM, Wieben ED (November 1988). "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins". The Journal of Biological Chemistry. 263 (33): 17772–9. doi:10.1016/S0021-9258(19)77902-2. PMID 2972723.
Stanford DR, Kehl M, Perry CA, Holicky EL, Harvey SE, Rohleder AM, Rehder K, Luhrmann R, Wieben ED (November 1988). "The complete primary structure of the human snRNP E protein". Nucleic Acids Research. 16 (22): 10593–605. doi:10.1093/nar/16.22.10593. PMC 338926. PMID 2974536.
Woppmann A, Rinke J, Lührmann R (December 1988). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Research. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
Kamiyama T, Aoki N, Yuasa Y (March 1993). "B-raf oncogene: activation by rearrangements and assignment to human chromosome 7". Japanese Journal of Cancer Research. 84 (3): 250–6. doi:10.1111/j.1349-7006.1993.tb02864.x. PMC 5919149. PMID 8098025.
Plessel G, Lührmann R, Kastner B (January 1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (January 2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". The Journal of Biological Chemistry. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". The Journal of Biological Chemistry. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.

v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

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