Thompson originally moved from England to the United States to be an archaeologist, but soon found herself drawn to comedy.[6] She began taking classes at the Upright Citizens Brigade in 2010, and is a member of their Maude team Alamo.[7] She is also the former host of the BBC America web series "Anglophenia", the co-host of the sketch comedy podcast Left Handed Radio, and has appeared in multiple television shows.[8][9]
She first appeared in a CollegeHumor sketch in May 2015,[10] and left the company at the end of 2016, before returning in late 2017.[citation needed]
Thompson is also a player on Dimension 20, a Dungeons & Dragonsactual play show which premiered September 2018 on the Dropout streaming service. Her characters include Adaine Abernant (Fantasy High series), Misty Moore/Rowan Berry (The Unsleeping City), Princess Ruby Rocks (A Crown of Candy), Iga Lisowski (The Unsleeping City: Chapter II), Riva (A Starstruck Odyssey), Princess Rosamund Du Prix (Neverafter), Imelda Pulse (Mentopolis), and a young stoat named Jaysohn (Burrow's End).[3][12] In addition, she has guested on other Dropout programs such as Game Changer.She has also been a guest player character on Not Another D&D Podcast as Apple Scrumper[13] and the Rotating Heroes Podcast as Astrid Starborn.