PROFILPELAJAR.COM

Shruti Naik

Shruti Naik
Alma materUniversity of Pennsylvania
Rockefeller University
University of Maryland, College Park
Scientific career
InstitutionsIcahn School of Medicine at Mount Sinai
ThesisHost-commensal cross talk at the cutaneous interface (2012)
Yasmine Belkaid

Shruti Naik is an Indian American scientist whose research focuses on immunology and adult stem cell biology. She is an Associate Professor of Immunology and Immunotherapy, Dermatology, and Institute of Regenerative Medicine and Director of the Tissue Repair Program at Icahn School of Medicine at Mount Sinai. Her lab integrates approaches from the fields of immunology, microbiology, stem cell biology, and cancer biology with imaging and sequencing technologies to investigate mechanisms underlying inflammatory diseases.

Her accolades include the Regeneron Prize for Creative Innovation, L'Oréal-UNESCO For Women in Science Award, the 2018 regional Blavatnik Awards for Young Scientists, and the International Takeda Innovator in Regeneration Award. Naik was named a Packard Fellow for her research into the molecular mechanisms that underpin the function of tissue stem cells.[1] She has also received the NIH Director's New Innovator Award and been named a Pew-Stewart Scholar and a New York Stem Cell Foundation Robertson Investigator. Most recently, she was awarded the LEO Foundation Award.[2]

Early life and education

Naik was born in India and moved to America at the age of twelve.[3] Naik dealt with the culture shock through humor and aspired to be a stand-up comedian.[3] Whilst a high school student, Naik came across the story of Dr. Bonnie Bassler, a biologist at Princeton University, who was working on quorum sensing mechanisms that make bacteria glow.[3] After watching Bassler on television, Naik decided she wanted to become a biologist and took classes in microbiology in high school.[3]

Naik was an undergraduate student at the University of Maryland, College Park, where she majored in cell and molecular biology.[4] As an undergraduate, Naik worked in the Food and Drug Administration laboratory on identifying microbes responsible for food-related outbreaks.[3] After graduating, Naik was appointed to the Naval Medical Research Center, where she looked at immune responses to traumatic brain injury.[3]

Naik earned her PhD at the University of Pennsylvania under the supervision of Dr. Yasmine Belkaid and Julie Segre.[5] She was a Damon Runyon Cancer Research postdoctoral fellow in the laboratory of Dr. Elaine Fuchs at Rockefeller University.[6]

Career and research

Naik studies how the immune system maintains the health of our tissues and organs over our lifetime. Naik is interested in the organs that interface with the external environment, including the skin, lungs, and gut.[7] She has investigated inflammation and tissue regeneration, host-microbe interactions, and inflammatory diseases.[7] Her research has included studies identifying that commensal microbes are necessary for proper developmental and function of the skin immune system, showing that skin stem cells can sense inflammation and exhibit inflammatory memory, and identifying new immunological factors that control cellular adaptation to hypoxia in wound repair. Her laboratory studies inflammatory diseases such as psoriasis and inflammatory bowel disease, non-healing wounds, and infectious diseases.

Naik has received grant funding from many organizations, including National Institutes of Health, Pew Charitable Trusts, The David and Lucile Packard Foundation, Kenneth Rainin Foundation, New York Stem Cell Foundation, National Psoriasis Foundation, and LEO Foundation. She is currently on the Scientific Advisory Board of Keystone Symposia.[8] In 2024, Naik was elected to serve as a Board Director for the Society for Investigative Dermatology.[9]

Research on skin microbiota and immunity

Naik's graduate research focused on the interactions between skin commensals and resident immune cells, and their role in cutaneous immunity.[10] She found that indigenous microbes co-opt tissue-specific modes of interacting with the host to direct immune cell function in the skin. She subsequently reported that certain commensal species are able to elicit a unique subset of IL-17A-producing CD8 T cells (Tc17s), indicating that sustaining complex communities of commensals is necessary to maintain a diverse repertoire of immune function. She then mapped the dendritic cell subsets necessary to sense commensals and induce long-term Tc17s.[11] This host - microbe dialogue takes place in the absence of overt inflammation in healthy skin. Therefore, these studies revealed a homeostatic immune response that is continuously calibrating barrier immunity to commensal signals.

Inflammatory memory in skin stem cells

Naik's research on skin stem cells identified how the skin 'remembers' injuries and exposure to irritants, finding that the long-lived epithelial stem cells in the skin encode a 'memory' or retain molecular changes associated with prior inflammatory stimuli. Repeated exposure can change the genetic landscape of stem cells, accelerating their response to subsequent inflammatory stimuli. This response can be beneficial, allowing for faster healing of wounds, or can be damaging and exacerbate inflammatory skin diseases such as psoriasis.[12] Naik continues this work to investigate how different cell types in complex tissue retain this molecular 'memory' of past inflammation and how these changes influence health and disease.

Immunity in tissue repair and inflammatory disease

Research from the Naik lab has examined how the immune system enables cells to adapt to hypoxia,[13] immune-tissue crosstalk in regeneration and repair processes,[14] spatial transcriptomics for stratification of psoriasis severity,[15] and approaches in regenerative medicine.[16] Naik's findings on hypoxia challenged previous models suggesting that hypoxia is sufficient to cell-autonomously induce HIF1α-mediated adaptation. The study found a secondary signal from repair-associated immune cells was required to activate HIF1α in the presence of hypoxia. Naik's work to understand how inflammatory factors fuel tissue repair is relevant to understanding disease states that are driven by immune-mediated tissue damage. This work may inform research into regenerative therapies for inflammatory and infectious disease that repair tissue. Naik later showed that, during early life, a specialized type of dendritic cell in the skin can directly activate IL-17-producing γδ T cells in response to allergens, identifying a developmental mechanism by which neuroendocrine maturation influences increased risk of inflammatory allergic reactions with age.[17]

Science outreach

Naik has spoken on not only her goals as a scientist ("discovery and bettering human health"), but also to make science more accessible to the world.[18] Naik has participated in scientific outreach, mentorship, and advocacy for women and other underrepresented groups in STEM. She has appeared on NBC,[18] NPR's Inflection Point,[19] Forbes Magazine,[20][21] and WIRED.[22] She has also been a panelist at several seminars focusing on career development and institutional barriers[23][24][25][26][27] and mentors trainees and researchers at various stages of their career, including high school student visitors, undergraduate trainees, doctoral candidates, postdoctoral fellows, professional researchers, and faculty.

In an interview with NBC, Naik discussed challenges she experienced as a woman of color in science, including being one of few people from similar backgrounds in professional settings, and emphasized the value of diversity in scientific research.[18]

Naik is an Executive Producer of "The Endless Frontier",[28] a feature-length documentary that follows three scientists and examines the scientific, institutional and funding challenges facing biomedical research.  

Awards and honors

References

  1. ^ a b visceral_dev_Admin (2020-10-15). "Packard Fellowships in Science and Engineering Announces New Class of Fellows in a Year of Connecting Virtually • The David and Lucile Packard Foundation". The David and Lucile Packard Foundation. Retrieved 2024-04-04.
  2. ^ a b https://leo-foundation.org/en/2024/05/17/new-york-skin-scientist-wins-prestigious-leo-foundation-award/
  3. ^ a b c d e f Gewin, Virginia (February 2017). "Turning point: Microbe detective". Nature. 542 (7639): 129. doi:10.1038/nj7639-129a. ISSN 1476-4687.
  4. ^ "2017 Sartorius Prize winners".
  5. ^ "Host-commensal cross talk at the cutaneous interface | WorldCat.org". search.worldcat.org. Retrieved 2024-04-04.
  6. ^ "Meet Our Scientists". Damon Runyon. Retrieved 2024-04-04.
  7. ^ a b "Shruti Naik". med.nyu.edu. Retrieved 2024-04-04.
  8. ^ "Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics". tks.keystonesymposia.org. Retrieved 2024-04-04.
  9. ^ https://www.sidnet.org/about/board/
  10. ^ Naik, Shruti; Bouladoux, Nicolas; Wilhelm, Christoph; Molloy, Michael J.; Salcedo, Rosalba; Kastenmuller, Wolfgang; Deming, Clayton; Quinones, Mariam; Koo, Lily; Conlan, Sean; Spencer, Sean; Hall, Jason A.; Dzutsev, Amiran; Kong, Heidi; Campbell, Daniel J. (2012-08-31). "Compartmentalized control of skin immunity by resident commensals". Science. 337 (6098): 1115–1119. doi:10.1126/science.1225152. ISSN 1095-9203. PMC 3513834. PMID 22837383.
  11. ^ Naik, Shruti; Bouladoux, Nicolas; Linehan, Jonathan L.; Han, Seong-Ji; Harrison, Oliver J.; Wilhelm, Christoph; Conlan, Sean; Himmelfarb, Sarah; Byrd, Allyson L.; Deming, Clayton; Quinones, Mariam; Brenchley, Jason M.; Kong, Heidi H.; Tussiwand, Roxanne; Murphy, Kenneth M. (2015-04-02). "Commensal-dendritic-cell interaction specifies a unique protective skin immune signature". Nature. 520 (7545): 104–108. doi:10.1038/nature14052. ISSN 1476-4687. PMC 4667810. PMID 25539086.
  12. ^ a b "Shruti Naik | Blavatnik Awards for Young Scientists". blavatnikawards.org. Retrieved 2024-04-04.
  13. ^ Konieczny, Piotr; Xing, Yue; Sidhu, Ikjot; Subudhi, Ipsita; Mansfield, Kody P; Hsieh, Brandon; Biancur, Douglas E; Larsen, Samantha B; Cammer, Michael; Li, Dongqing; Landén, Ning Xu; Loomis, Cynthia; Heguy, Adriana; Tikhonova, Anastasia N; Tsirigos, Aristotelis (2022-07-01). "Interleukin-17 governs hypoxic adaptation of injured epithelium". Science. 377 (6602) eabg9302. doi:10.1126/science.abg9302. ISSN 1095-9203. PMC 9753231. PMID 35709248.
  14. ^ Guenin-Mace, Laure; Konieczny, Piotr; Naik, Shruti (2023-04-26). "Immune-Epithelial Cross Talk in Regeneration and Repair". Annual Review of Immunology. 41: 207–228. doi:10.1146/annurev-immunol-101721-062818. ISSN 1545-3278. PMC 10750769. PMID 36696569.
  15. ^ Castillo, Rochelle L.; Sidhu, Ikjot; Dolgalev, Igor; Chu, Tinyi; Prystupa, Aleksandr; Subudhi, Ipsita; Yan, Di; Konieczny, Piotr; Hsieh, Brandon; Haberman, Rebecca H.; Selvaraj, Shanmugapriya; Shiomi, Tomoe; Medina, Rhina; Girija, Parvathy Vasudevanpillai; Heguy, Adriana (2023-06-08). "Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems". Science Immunology. 8 (84) eabq7991. doi:10.1126/sciimmunol.abq7991. ISSN 2470-9468. PMC 10502701. PMID 37267384.
  16. ^ McKinley, Kara L.; Longaker, Michael T.; Naik, Shruti (2023-05-26). "Emerging frontiers in regenerative medicine". Science. 380 (6647): 796–798. doi:10.1126/science.add6492. ISSN 1095-9203. PMC 10493035. PMID 37228215.
  17. ^ Xing, Yue; Reznikov, Ilana; Ahmed, Abonti Nur; Sidhu, Ikjot; Wisnewski, Jill; Farhat, Asma; Prystupa, Aleksandr; Konieczny, Piotr; Mansfield, Kody; Cooper, Melissa L.; Yeung, Stephen T.; Kim, Madeline; Anandasabapathy, Niroshana; Naik, Shruti (2026). "Peripheral immune-inducer dendritic cells drive early-life allergic inflammation". Nature. 652 (8112): 1308–1317. doi:10.1038/s41586-026-10162-x.
  18. ^ a b c "'Be comfortable with being uncomfortable': See how this scientist is opening doors for women in STEM". MSNBC.com. Retrieved 2024-04-04.
  19. ^ "Inspiring More Women in Science - Dr. Shruti Naik, The Rockefeller University". Inflection Point. 2017-01-23. Retrieved 2024-04-04.
  20. ^ Gasman, Marybeth. "Why Supporting Women Cancer Researchers Leads To Victory". Forbes. Retrieved 2024-04-04.
  21. ^ Wight, Andrew. "How Does The Immune System's 'Memory' Influence Cancer Susceptibility?". Forbes. Retrieved 2024-04-04.
  22. ^ Immunologist Answers Immune System Questions From Twitter | Tech Support | WIRED. Retrieved 2024-04-04 – via www.youtube.com.
  23. ^ "Kellen WEF Events". Translational Research. Retrieved 2024-04-04.
  24. ^ Branch, NIAMS Science Communications and Outreach (2021-02-26). "NIAMS Forum for Clinical Mentored K Awardees - December 2020". National Institute of Arthritis and Musculoskeletal and Skin Diseases. Retrieved 2024-04-04.
  25. ^ "Changing the Face of STEM". www.loreal.com. Retrieved 2024-04-04.
  26. ^ "Past Meetings | Montagna Symposium on the Biology of Skin". Retrieved 2024-04-04.
  27. ^ "NYSCF Community Showcased at the International Society for Stem Cell Research Conference". New York Stem Cell Foundation. Retrieved 2024-04-04.
  28. ^ "Home". Six Degrees from Science. Retrieved 2024-04-04.
  29. ^ "Regeneron Announces 2015 Winners of the Regeneron Prize for Creative Innovation" (Press release). Regeneron Pharmaceuticals. June 25, 2015. Retrieved 2026-07-08.
  30. ^ "Dr. Shruti Naik: Discovery, Disease, and the Empowerment of Women Scientists". The Scientista Foundation. Retrieved 2024-04-04.
  31. ^ "Inspiring Women in Science". www.nature.com. Retrieved 2024-04-04.
  32. ^ "Dale F. Frey Breakthrough Scientists: Current and Former Awardees". Damon Runyon. Retrieved 2024-04-04.
  33. ^ "2018 Award Highlights".
  34. ^ "Our Stories Gallery | Takeda Pharmaceuticals". www.takeda.com. Retrieved 2024-04-04.
  35. ^ "Research Grants". The Skin Cancer Foundation. Retrieved 2024-04-04.
  36. ^ "Shruti Naik, Ph.D." pew.org. Retrieved 2024-04-04.
  37. ^ "2020 Awardees | NIH Common Fund". commonfund.nih.gov. Archived from the original on October 16, 2021. Retrieved 2024-04-04.
  38. ^ "Search Grantees". Kenneth Rainin Foundation. Retrieved 2024-04-04.
  39. ^ "ICIS-Regeneron New Investigator Awards - International Cytokine & Interferon Society". 2021-04-26. Retrieved 2024-04-04.
  40. ^ "Shruti Naik, PhD". New York Stem Cell Foundation. Retrieved 2024-04-04.
  41. ^ "McClintock Lectures – CSHL WiSE". Retrieved 2024-04-04.
  42. ^ "BWF Announces Recipients of the Investigators in the Pathogenesis of Infectious Disease Award". Burroughs Wellcome Fund. Retrieved 2024-04-04.
  43. ^ https://ampaim.omrf.org/leadership-scholar-program/


{{|url=https://commonfund.nih.gov/newinnovator/awardrecipients}}

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.