Shmuel Horowitz may refer to:

• Shmelke of Nikolsburg (1726–1778), also known as Shmuel Shmelke Halevi Horowitz, early Hasidic Rebbes
• Shmuel Horowitz (publisher) (1903–1973), compiler and publisher of Chayey Moharan, a biography of Rabbi Nachman of Breslov
• Shemp Howard, comedian, actor and talent agent

• Shmuel Hurwitz (1901-1999), Israeli agronomist

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