Kale was born the eldest son of the family of seven on June 6, 1904, in Ipata, Mobalufon, in Odogbolu Local Government of Ogun State. His parents Pa Jacob and Mama Victoria Kale were said to be the first Christian converts in the village. At birth he was given the Yoruba nameIrunsewe meaning “we” (this one) “se” (happen); “irun” (nothing at all). On June 25, 1904 he was baptized with the name Seth.
Kale returned from London and was immediately appointed the acting principal of CMS Grammar School, Lagos, it took only three years before he became the first Nigerian to be appointed principal of the school in the twentieth century. In 1921, He was one of the founding members of the National Union of Teachers, including Vice-Principal, Jonathan Lucas and Rev. I.O Ransome-Kuti.[4] He was still a principal at CMS Grammar School, Lagos when he became a deacon at the Cathedral Church of Christ, Lagos in 1942, he was ordained a priest on the anniversary of his diaconate in 1943. He became the first Nigerian principal of the long established St. Andrew’s Teachers’ Training College, Oyo, in 1951.[5] He was credited for restoring law and order in the college after years of alleged prejudices, class distinctions, and social differences, which had plagued the college. In 1963, at the Assembly of Church Prelates in Toronto, Rev. Kale was elected the Bishop of Lagos and was consecrated on November 30, 1963.