His main scientific interests are in immunochemical analysis of peptide and proteinantigenic structure. He was the founder of molecular immunology studies in Ukraine; his team was the first in the former Soviet Union to implement immunoenzyme methods, monoclonal antibody technique, and flow cytofluorimetry in research.
He was the head of the Ukrainian Scientific Immunology Program; under his guidance it was found that low-dose radiation from Chernobyl fall-out decreased the number and activity of natural killer cells in humans. This immune suppression he named "Chernobyl AIDS".[1]
Komisarenko was Deputy Prime Minister of Ukraine from 1990 to 1992, responsible for public health, science and technology, education, culture, and religion.
He was the first Ambassador Plenipotentiary to the United Kingdom from 1992 to 1998, and to Ireland from 1995 to 1998. In 1999, he was campaign manager for presidential candidate Evgen Marchuk.
His 2004 presidential election program included a guarantee of a state monopoly for the manufacturing of tobacco and alcohol products, and gradual political reform after the 2006 parliamentary elections. In his program, he paid great attention to the development of science and education. In international relations he favours a policy of neutrality.
