Telle served as Consul General (later Ambassador) of France to Monaco from 2002 to 2007.[1] He was an advisor to Foreign Minister Bernard Kouchner from 2007 to 2008.[1][2] He was the French ambassador to the Union for the Mediterranean from 2008 to 2012, and the interministerial delegate for the Mediterranean from 2013 to 2015.[1] He was also the president of the Agency for Cities and Territories of the Mediterranean from 2011 to 2016.[1] Telle was appointed Minister of State of Monaco on 1 February 2016, succeeding Michel Roger.[3][4]
On 16 March 2020 Telle tested positive for COVID-19.[5]
From his first marriage with Karène Telle, he has 3 children named Anne-Claire, Jean-Baptiste and Antoine. After getting divorced, he met and married Guilaine Chenu, a television presenter.[2][6] They have a son, Alexis.[7]