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SEMA3E
Identifiers
Aliases	SEMA3E, M-SEMAH, M-SemaK, SEMAH, coll-5, semaphorin 3E
External IDs	OMIM: 608166; MGI: 1340034; HomoloGene: 8247; GeneCards: SEMA3E; OMA:SEMA3E - orthologs
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	14,306,703 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; islet of Langerhans; ; gallbladder; ; gastric mucosa; ; synovial membrane; ; urinary bladder; ; synovial joint; ; rectum; ; prefrontal cortex; ; ganglionic eminence;
	Top expressed in
	lumbar spinal ganglion; ; pontine nuclei; ; decidua; ; habenula; ; gastrula; ; right lung; ; right lung lobe; ; vestibular membrane of cochlear duct; ; Region I of hippocampus proper; ; substantia nigra;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; neuropilin binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	extracellular region; extracellular space; integral component of plasma membrane;
Biological process	cell differentiation; nervous system development; multicellular organism development; angiogenesis; negative chemotaxis; branching involved in blood vessel morphogenesis; negative regulation of cell-matrix adhesion; sprouting angiogenesis; regulation of cell shape; negative regulation of angiogenesis; synapse organization; semaphorin-plexin signaling pathway; regulation of actin cytoskeleton reorganization; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance;
	Sources:Amigo / QuickGO
Orthologs
	9723
	20349
	n/a
	ENSMUSG00000063531
	O15041
	P70275
	NM_001178129; NM_012431
	NM_011348
	NP_001171600; NP_036563
	NP_035478
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene. ^[4]

Function

Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.

This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063531 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Semaphorin 3E". Retrieved 2018-04-26.