Second Presbyterian Church may refer to:

• Second Ballyeaston Presbyterian Church, a congregation of the Presbyterian Church in Ireland

• Second Presbyterian Church (Guilford, Baltimore, Maryland), church of Franklin L. Sheppard
• Second Presbyterian Church (Birmingham, Alabama), listed on the NRHP in Alabama
• Second Presbyterian Church (Chicago, Illinois), listed on the NRHP in Illinois
• Second Presbyterian Church (Indianapolis, Indiana)
• Second Presbyterian Church (Lexington, Kentucky), listed on the NRHP in Kentucky
• Second Presbyterian Church (St. Louis, Missouri), listed on the NRHP in Missouri
• Second Presbyterian Church (Princeton, New Jersey), merged with Nassau Presbyterian Church
• Second Presbyterian Church (Columbus, Ohio), listed on the NRHP in Ohio
• Second Presbyterian Church (Portsmouth, Ohio), listed on the NRHP in Ohio
• Second Presbyterian Church (Chattanooga, Tennessee), listed on the NRHP in Tennessee
• Second Presbyterian Church (Memphis, Tennessee) (1891), listed on the NRHP in Tennessee
• Second Presbyterian Church (Memphis, Tennessee) (1952)
• Second Presbyterian Church (Petersburg, Virginia), listed on the NRHP in Virginia
• Second Presbyterian Church (Richmond, Virginia), listed on the NRHP in Virginia

This disambiguation page lists articles associated with the title Second Presbyterian Church.
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