Sean O'Brien may refer to:

• Seán O'Brien (Gaelic footballer), Gaelic footballer for Nemo Rangers
• Seán O'Brien (Cork hurler) (1926–?), Irish hurler
• Seán O'Brien (Tipperary hurler), Irish hurler
• Sean O'Brien (ice hockey) (born 1972), American former ice hockey left winger
• Seán O'Brien (rugby union, born 1987), former Irish rugby union international flanker for Leinster and London Irish
• Seán O'Brien (rugby union, born 1994), former Irish rugby union flanker for Connacht
• Seán O'Brien (rugby union, born 1998), Irish rugby union centre / winger for Munster
• Seán O'Brien (rugby union, born 2000), American-born Irish rugby union flanker for Connacht
• Sean O'Brien (windsurfer) (born 1984), Australian windsurfer
• Sean O'Brien (footballer), English footballer

• Sean O'Brien (writer) (born 1952), British writer
• Sean C. O'Brien, co-discoverer of buckminsterfullerene
• Sean O'Brien (labor leader), American trade unionist
• Sean O'Brien (musician), bassist and original member of Boston rock band Come
• Sean O'Brien (Ohio politician) (born 1969), Democratic member of the Ohio Senate

• John O'Brien (disambiguation)
• Sean O'Bryan (born 1963), American actor
• Shaun O'Brien (disambiguation)

Topics referred to by the same term

This disambiguation page lists articles about people with the same name.
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