Giambrone started his acting career at age nine, starring in television commercials for McDonald's and Friendly's Restaurants, among others.[6] His first film role came in 2012, where he played Afro Boy in I Heart Shakey.
From 2014 to 2018, Giambrone provided the voice of Jeff Randell, the title character's best friend, on the Cartoon Network animated series Clarence. He also made an appearance in R.L. Stine's The Haunting Hour, and provided the voice of a bull terrier named Russell in the 2015 DVD film Russell Madness. In 2019, Giambrone co-starred with Sadie Stanley in the film Kim Possible, where he played Ron Stoppable, the best friend and sidekick of Stanley’s title character, and was credited in the soundtrack.
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