Sca-1 stands for "Stem cells antigen -1" (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol -anchored cell surface protein (GPI-AP) of the LY6 gene family .[ 1] biological marker used to identify hematopoietic stem cell (HSC) along with other markers.
Application of Sca-1
Sca-1 has a regenerative role in cardiac repair: Host cells with specific Sca-1+CD31− markers arise upon myocardial infarction , with evidence of expression of Sca-1 protein.[ 2]
Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression.[ 3]
References
^ Holmes, Christina; Stanford, William L. (June 2007). "Concise Review: Stem Cell Antigen-1: Expression, Function, and Enigma" . Stem Cells . 25 (6): 1339–1347. doi :10.1634/stemcells.2006-0644 PMID 17379763 . S2CID 6514438 . ^ Wang, X; Hu, Q; Nakamura, Y; Lee, J; Zhang, G; From, AH; Zhang, J (2006). "The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling" . Stem Cells . 24 (7): 1779–1788. doi :10.1634/stemcells.2005-0386 PMID 16614004 . ^ Bradfute, Steven B.; Graubert, Timothy A.; Goodell, Margaret A. (July 2005). "Roles of Sca-1 in hematopoietic stem/progenitor cell function" . Experimental Hematology . 33 (7): 836–843. doi :10.1016/j.exphem.2005.04.001 PMID 15963860 .
