Santisima Trinidad (meaning Most Holy Trinity in Spanish) may refer to:

• Santísima Trinidad (fort), a fortress that once existed on the Bio Bio River in Bio Bío province, Chile
• Santísima Trinidad (Asunción), a barrio (district) in Asunción, Paraguay and home of the football club Sportivo Trinidense
• La Santísima Trinidad de Paraná, a former Jesuit mission in Paraguay
• Santisima Trinidad (Taiwan), a Spanish settlement from 1626 to 1642 on the island of Formosa

• One of several Spanish ships including:
  • Santísima Trinidad (1600s), a 400-ton galleon, which escaped when Panama City was attacked in 1671 and was later captured by English buccaneers
  • Spanish ship Santísima Trinidad (1751) – largest of the Manila galleons; officially named Santísima Trinidad y Nuestra Señora del Buen Fin, captured by the British in 1762
  • Spanish ship Nuestra Señora de la Santísima Trinidad (1769), world's largest warship in its time, until it sank after the Battle of Trafalgar (1805)
• One of several Argentine warships including:
  • Santísima Trinidad (1814), a brigantine of the Independence Wars era
  • ARA Santísima Trinidad (D-2), a Type 42 destroyer in service with the Argentine Navy 1981–1989.

• Buenos Aires, Argentina - its original name in 1560 was Ciudad de la Santísima Trinidad, Puerto de Buenos Aires
• Roman Catholic Archdiocese of Buenos Aires - Santísima Trinidad was an alternative title in the early 20th century
• ARA Santísima Trinidad - page listing all Argentine Navy ships with this name

This disambiguation page lists articles associated with the title Santísima Trinidad.
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