Santiago is the capital city of Chile.

Santiago may also refer to:

• Four other notable cities often referred to as simply "Santiago":
  • Santiago de Compostela, Spain
  • Santiago de Cuba, Cuba
  • Santiago de los Caballeros, Dominican Republic
  • Santiago, Isabela, Philippines

• Santiago del Estero Province
  • Santiago del Estero, capital of the province

• Santiago, Rio Grande do Sul

• Santiago, Cape Verde

• Santiago (commune)
• Santiago Province, Chile
• Santiago Metropolitan Region

• Santiago, Norte de Santander
• Santiago, Putumayo
• Santiago de Cali

• Santiago District, Palmares
• Santiago District, Paraíso
• Santiago District, Puriscal
• Santiago District, San Rafael
• Santiago District, San Ramón

• Santiago de Cuba Province
  • Santiago de Cuba, capital of the province
  • Battle of Santiago de Cuba
• Santiago de las Vegas

• Santiago Province (Dominican Republic)

• Santiago de Guayaquil, coastal city
• Santiago de Quito, 1534 Spanish settlement in Colta Canton, Chimborazo, moved north later that year and renamed San Francisco de Quito
• Santiago Island (Galápagos)

• Santiago Sacatepéquez, Guatemala
• Santiago Atitlán, Guatemala, the capital of the Tz'utujil people in pre-Columbian times

• Santiago, a Spanish possession that later became Jamaica
• Spanish Town or Santiago de la Vega, Jamaica

• Querétaro City, Querétaro
• Santiago el Pinar, Chiapas
• Santiago, Nuevo León
• Santiago, Baja California Sur
• Santiago River (Eastern Mexico), a river of Veracruz
• Santiago River (Mexico), the outlet of Lake Chapala and the longest river entirely in Mexico
• Santiago Maravatío, Guanajuato
• Santiago Tianguistenco, a city in the State of México
• Santiago, Oaxaca (disambiguation), several places
• Baluarte de Santiago, a fortification in Veracruz
• Santiago Ixcuintla, a city in Nayarit

• León, Nicaragua or Santiago de los Caballeros de León

• Santiago District, Veraguas, a district of Veraguas Province
• Santiago (corregimiento), the seat of Santiago District
• Santiago de Veraguas, the capital of Veraguas Province

• Santiago, Paraguay, a town and district in Misiones Department

• Santiago District, in Cusco Province of the Cusco Region
• Santiago de Surco, a district of Lima
• Santiago de Chuco, Santiago de Chuco District, a province of the La Libertad region
• Santiago River (Peru), a tributary of the Marañón River

• Santiago, Agusan del Norte
• Santiago, Ilocos Sur
• Cape Santiago, a cape at the southwestern tip of Luzon
• Santiago Island (Pangasinan), an island off of western Luzon

• Santiago (Lisbon), a parish in the municipality of Lisbon
• Santiago (Tavira), a parish in the municipality of Tavira
• Santiago do Cacém, a parish and a municipality in the Setúbal
• Santiago de Piães, a parish in the municipality of Cinfães
• Vale de Santiago, a parish in the municipality of Odemira
• Santiago Maior (Beja), a parish in the municipality of Beja, Portugal

• Santiago River (Puerto Rico), a short river in Naguabo
• Caño de Santiago, a channel in Yabucoa, Puerto Rico

• Santiago (Valdés), a parish in the municipality of Valdés, Asturias
• Santiago (Sariego), a parish in the municipality of Sariego
• Santiago (comarca), a comarca in the province of A Coruña
• Santiago del Teide, Tenerife, Canary Islands
• Playa Santiago, La Gomera, Canary Islands

• Cape Santiago (Taiwan), a cape at the northeastern tip of Taiwan

• Santiago, West Virginia
• Santiago Canyon, California
• Santiago Peak, a mountain in Orange County, California
• Santiago High School (Garden Grove, California), Garden Grove, California
• Santiago High School (Corona, California), Corona, California
• Santiago Township, Sherburne County, Minnesota
• Santiago, Minnesota, an unincorporated community
• Santiago, Pennsylvania, an unincorporated community
• Santiago Peak (Texas), a mountain in Brewster County, Texas

• Montevideo or San Felipe y Santiago de Montevideo

• Santiago de León de Caracas
• Santiago de Los Caballeros de Mérida, Venezuela

• Santiago (name), a Spanish given name
• Santiago (surname)
• James the Great (Spanish: Santiago), one of the Twelve Apostles of Jesus
• Santiago (footballer, born 1976), full name Elisandro Naressi Roos, Brazilian footballer
• Santiago (footballer, born 1980), full name Petrony Santiago de Barros, Brazilian footballer
• Santiago (footballer, born 1984), full name Rafael Santiago Maria, Brazilian footballer

• Santiago (caravel) [es], one of the ships of the Magellan Expedition
• Santiago (1551), a supply ship of the Spanish Armada that wrecked south of Bergen, Norway, in 1588
• Santiago (1856), a British barque, now in the Garden Island Ships' Graveyard near Port Adelaide, Australia
• Santiago, an American schooner barge that operated with the SS Appomattox until its wreck

• Santiago (album), a 1996 album by The Chieftains
• Santiago (band), an American indie/punk band
• "Santiago", a song by Loreena McKennitt from The Mask and Mirror
• Santiago (1956 film), an American film directed by Gordon Douglas
• Santiago (2007 film), a Brazilian film directed by João Moreira Salles

• Santiago City FC, a Chilean association football club
• Santiago (genus), a genus of Eucerine bees
• Santiago (horse), racehorse, winner of the 2020 Irish Derby
• Santiago (The Vampire Chronicles), in Anne Rice's novel Interview with the Vampire
• Santiago (volleyball club), a women's team in Santiago, Dominican Republic
• ¡Santiago!, a shortened form of the Reconquista battle cry "Santiago y cierra, España"
• Order of Santiago, a Spanish knightly order
• Tarta de Santiago, an almond cake or pie from Spain with origin in the Middle Ages
• A nickname for the version 6 beta of the Red Hat Enterprise Linux operating system
• Santiaogou Republic, an historical Chinese kongsi federation in Borneo, sometimes spelled "Santiago Republic"

• Santiago Island (disambiguation)
• Santiago Maior (disambiguation)
• Santiago Province (disambiguation)
• Santiago River (disambiguation)
• All pages with titles containing Santiago (disambiguation)
• Saint James (disambiguation)
• San Diego (disambiguation)
• Diogo (disambiguation)
• São Tiago