In addition to Santa Maria, the district serves the communities of Bluetown and Iglesia Antigua.
Santa Maria ISD has three campuses - Santa Maria High School (grades 9-12), Santa Maria Middle (grades 5-8), and Tony Gonzalez Elementary (prekindergarten - grade 4).
As of 2007, the Texas State Energy Conservation Office awards Santa Maria ISD money due to the colonias served by the district.[1]