Her first novel, The River Where Blood Is Born, inspired by a trip to Africa in 1975,[6] was published in 1997, winning the American Library Association Black Caucus Award for Best Fiction. The review in the Chicago Sun-Times said: "Besides its sheer literary beauty, Jackson-Opoku’s story-weaving will give readers a new spiritual dimension from which to consider the meaning of life."[7] She is also the author of a 2001 novel, about which Publishers Weekly wrote: "Jackson-Opoku's ability to craft memorable characters with distinct temperaments and sensibilities marks her as a writer to be reckoned with."[8] As a children's writer, she has received the Society of Children's Book Writers and Illustrators Colen Award in New Children's Writing and a Maeve Marie Fellowship for Children’s Writing at the Writers' Colony at Dairy Hollow.[9]
To mark what would have been the 100th birthday of Gwendolyn Brooks (1917–2000), Jackson-Opoku co-edited, with Quraysh Ali Lansana, the anthology Revise the Psalm: Work Celebrating the Writing of Gwendolyn Brooks (2017).[10][11] Featuring contributions from such writers as Angela Jackson, Sandra Cisneros, Rita Dove, and Diane Glancy,[12] it was described in The Chicago Review of Books as "absolutely essential reading for anyone hoping to understand the impact Brooks made on the arts and activism, not just in Chicago but throughout the country."[13] In a review for The New York Times, Claudia Rankine wrote that in Revise the Psalm "we get a keen sense of the poet and her fierce commitment to community engagement".[14]
She has taught Literature and Creative Writing at Chicago State University and at Columbia College,[21] as well as at other educational institutions and at workshops around the world.
In July 2020, she was listed as one NewCity's "Lit 50", Chicago's annual Hall of Fame honouring the city's literary community.[22]