The Sand River Convention that led to the independence of the Transvaal Republic was signed in a marquee on the banks of the Sand River on 17 January 1852. A monument commemorating the ceremony can today be found on the banks of the river some 15 kilometres (9.3 mi) from Winburg.[4]
On 25 March 25, 1900, during the guerrilla phase of the Anglo-Boer War, a Council-of-War led by the Boers that wanted to continue with the hostilities was held at a bridge over the Sand River.[5]
In 1988 the Sand River burst its banks and flooded parts of Virginia town. In 1994 the Merriespruit tailings dam disaster occurred just outside Virginia, killing seventeen people.[6]
The river was named after an incident where a wagon got bogged down in its sand, and had to be unloaded before the journey could continue.[2]