The plain stone church was granted in 1251 for a community of Franciscan friars. The interior has marble monuments to members of the aristocratic family of Counts Guidi, who were patrons of the order. The monument to Bishop Jacopo Guidi (1588) was designed by Felice Palma.[1]
Above the main altar, now enclosed in a baroque marble frame consisting of clouds, putti, and angels, is an early 14th century painted icon depicting a Madonna and Child. The venerated image of the Madonna di San Sebastiano was moved here from the no longer extant church of San Sebastiano.[2]
Among the paintings in the side altars flanking the nave is a Madonna of the Immaculate Conception and Saints with Adam and Eve (1585) by Giovanni Battista Naldini, a Nativity (1591) by Giovanni Balducci, a Crucifixion attributed to Bartolomeo Neroni, and a Crucifixion (1602) painted by Cosimo Daddi. There is an altarpiece depicting the "Miracle of San Francesco di Paola crossing the Straits of Messina on his Mantle" (1711) by Alessandro Gherardini. The baptismal font was sculpted by Giovanni Battista Bava in 1552. The sacristy had a painting depicting Adoration of the Magi by Ignazio Hugford and a Nativity by Vincenzo Ferretti.[3]