Samuel Krimm

Samuel Krimm
Born (1925-10-19) October 19, 1925 (age 99)[2]
Morristown, New Jersey[2]
Alma mater
Awards
Scientific career
FieldsBiophysics
InstitutionsUniversity of Michigan
Doctoral studentsWillie Hobbs Moore[1]

Samuel Krimm (born October 19, 1925) is an American physicist with a research focus in biophysics (spectroscopy, macromolecules, protein folding). He is professor emeritus and research scientist emeritus at University of Michigan.[3][4]

Education

Krimm earned a BS in chemistry, from Polytechnic Institute of Brooklyn (1947), and MS and PhD in physical chemistry from Princeton University (1949, 1950).[5]

Career highlights

Krimm was elected fellow of the American Physical Society in 1959.[6]

In 1977, Krimm received the American Physical Society's Polymer Physics Prize "For his outstanding experimental studies and theoretical developments in infrared and Ra-man spectroscopy and X-ray scattering from natural and synthetic polymers".[6]

In 1983, he was awarded the Humboldt Prize.[7]

From 1967-1972 he was doctoral advisor for Willie Hobbs Moore, who earned the first PhD in physics for an African-American woman at an American university.[1]

He was the first Director of the University of Michigan Program in Protein Structure and Design, created in 1985.[8]

He has published over 300 peer-reviewed articles, on the infrared and Raman spectroscopy of synthetic polymers and proteins, and in the field of theoretical and computational studies of the structures of such macromolecules.[9]

In his most recent work, he and colleague/collaborator Noemi Mirkin have proposed a new paradigm in the field of protein folding they term "milieu folding" demonstrating that the presence of particular molecules in the surrounding aqueous environment of a protein molecule ("milieu") can alter the propensities for the folded structure of the protein. They suggest that this is a more appropriate framework than "misfolding" to explore and understand protein-folding diseases.[10][11]

References

  1. ^ a b Mickens, Ronald E. (2022). "The trailblazing career of Willie Hobbs Moore". Physics Today. 75 (9): 30–35. doi:10.1063/PT.3.5080.
  2. ^ a b Krimm, Samuel (July 2010). "Biography". Faculty Memoir Project. University of Michigan.
  3. ^ "Samuel Krimm physics emeritus faculty page". University of Michigan College of Literature, Science and the Arts. Retrieved August 29, 2024.
  4. ^ "Samuel Krimm biophysics emeritus faculty page". University of Michigan College of Literature, Science and the Arts. Retrieved August 29, 2024.
  5. ^ "Samuel Krimm macromolecular emeritus faculty page". Michigan Engineering. Retrieved August 29, 2024.
  6. ^ a b "American Physical Society, Samuel Krimm, fellow 1959, Polymer Physics Prize 1977". American Physical Society. Retrieved August 29, 2024.
  7. ^ "Humboldt Prize, Samuel Krimm 1983". Retrieved August 29, 2024.
  8. ^ "Biophysics History". University of Michigan. Retrieved August 29, 2024.
  9. ^ "Samuel Krimm bibliography". ResearchGate. Retrieved August 29, 2024.
  10. ^ Mirkin, Noemi G.; Krimm, Samuel (2018). "Milieu-Initiated Inversion of the Aqueous Polyproline II/β Propensity in the Alanine Tripeptide: Aggregation Origin of the Onset of Amyloid Formation" (PDF). J. Phys. Chem. B. 122: 4428−4432. doi:10.1021/acs.jpcb.8b00612.
  11. ^ Mirkin, Noemi G.; Krimm, Samuel (July 2020). "Hydrogen sulfide concentration in the milieu of the hydrated alanine dipeptide determines its polyproline II‐beta propensity: Main chain contribution to the energetic origin of the formation of amyloid". Biopolymers. 111 (7). doi:10.1002/bip.23356. hdl:2027.42/156236.