Sam Holt or Samuel Holt may refer to:

• Samuel Holt (1880–1929), Irish politician
• Sam B. Holt (1902–1986), American football, basketball, and baseball coach and athletics administrator
• Samuel C. O. Holt (born 1936), public television and radio executive
• Lynching of Sam Hose (aka Sam Holt, c. 1875 – 1899), African American lynched in Coweta County, Georgia

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