Saint Antoninus may refer to:

• Antoninus of Rome (died 186), martyr
• Antoninus of Pamiers (first, second, fourth, or fifth century), missionary and martyr, called the "Apostle of the Rouergue"
• Antoninus of Syria (died 303), martyr
• Antoninus of Piacenza (died 303), patron saint of Piacenza
• Antoninus Fontana (Antonino Fontana), archbishop of Milan (died 661)
• Antoninus of Florence (1389–1459)
• Antoninus of Sorrento (died 830 AD)

This disambiguation page lists articles associated with the title Saint Antoninus.
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