Born and raised in Philadelphia, Jones moved to New York City to study painting at Pratt Institute.[2] She began writing and illustrating comics in the 1980s, inspired by the societal tumult of the Reagan era and the revived conservative focus on repealing abortion and other reproductive rights.[3] She joined a group of pro-choice activist artists called Carnival Knowledge.[3]World War 3 Illustrated co-founder Seth Tobocman convinced Jones to create her first comic strip for the magazine.[citation needed] She went on to edit and contribute to many issues of World War 3 Illustrated, including "Bitchcraft,"[4] "Female Complaints,"[5] and "Life During Wartime."[6]
In 2002, Jones' work was included in the exhibition "She Draws Comics: Trina Robbins and 27 Women Cartoonists", curated by Trina Robbins, shown at the Secession Gallery, Vienna, Austria; the exhibition toured to the Museum of Comic and Cartoon Art (New York City) in 2006.[8]
Jones created her first historical comics for Wobblies! A Graphic History of the Industrial Workers of the World, published by Verso Books in 2005. Her work on The Real Cost of Prisons Comix inspired her to create Mixed Signals,[citation needed] a counter-recruitment tool in comic book form. Her first long-form graphic novel was Isadora Duncan: a Graphic Biography, published in 2008 by Hill & Wang.
2010 saw one of Jones' first collaborations with a writer — Paul Buhle. Buhle wrote the text for FDR and the New Deal for Beginners, which was illustrated entirely by Jones. The mixture of a graphic novel and a history book by Buhle and Jones was the latest in the long line of For Beginners books. Jones' artwork was noted by one reviewer for its "thick, darkened contours . . . – like film noir invaded by grainy newsreel footage in a Brechtian landscape."[9]
In 2013 Jones wrote and drew Race to Incarcerate: A Graphic Retelling, an adaptation of Marc Mauer's book on America's exploding imprisonment rate.[10][11]
In 2016, Soft Skull Press published Jones' graphic novel Our Lady of Birth Control: A Cartoonist's Encounter with Margaret Sanger, which told Sanger's biography through the lens of Jones' own experiences during the sexual revolution.[12][3]
In addition to being a fine art painter, Jones has worked consistently as a scenic artist since 1990, painting scenery for film, theater, and television.[13] In 1994, as a new member of United Scenic Artists Local 829[13] Jones began weekly work for Saturday Night Live's broadcasts,[10] a practice that continues to this day.[13]
GirlTalk (4 issues, Fantagraphics, 1995–1996) — co-editor and contributor
Wobblies! A Graphic History of the Industrial Workers of the World (Verso Books, 2005) ISBN978-1844675258 — contributing cartoonist; edited by Paul Buhle and Nicole Schulman
Nature Comics #3 (Nature, 2008) — contributed the story "Good Wolf / Bad Wolf"
The Real Cost of Prisons Comix (PM Press, 2008) ISBN9781604860344 — contributed the story "Prisoners of the War on Drugs"