SPO may refer to:

• Serbian Renewal Movement (Srpski pokret obnove), a political party in Serbia
• Socialist Party of Ontario, Canada
• Strengthening Participatory Organization, a rights-based organization in Pakistan
• SPÖ, Social Democratic Party of Austria
• Party of Civic Rights, political party in the Czech Republic

• Secondary phosphine oxide, a class of organophosphorus compounds
• SharePoint Online

• Saint Paul's Outreach, a Catholic missionary organization
• SPO:), a Lithuanian sports magazine
• SPO Rouen Basket, a basketball club in Rouen, France
• Scholarly Publishing Office, University of Michigan University Library
• Seoul Philharmonic Orchestra, a South Korean orchestra based in Seoul
• Strong Pareto optimum, in economics
• Supreme Prosecutors' Office of the Republic of Korea
• Erik Spoelstra, head coach of the Miami Heat
• Sankt Peter-Ording, a tourist town in northern Germany

• Spo11, a protein used in a complex along with Mre11 and Rad50 during meiotic recombination
• SPOC (disambiguation)

This disambiguation page lists articles associated with the title SPO.
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