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SERTAD1
Identifiers
Aliases	SERTAD1, SEI1, TRIP-Br1, SERTA domain containing 1, TRIPBR1
External IDs	OMIM: 617850; MGI: 1913438; HomoloGene: 8365; GeneCards: SERTAD1; OMA:SERTAD1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	40,425,992 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	27,189,741 bp
RNA expression pattern
	Top expressed in
	vena cava; ; amniotic fluid; ; lower lobe of lung; ; mucosa of ileum; ; saphenous vein; ; trachea; ; mucosa of pharynx; ; tibialis anterior muscle; ; pancreatic epithelial cell; ; gastric mucosa;
	Top expressed in
	granulocyte; ; intestinal villus; ; ascending aorta; ; aortic valve; ; sciatic nerve; ; lip; ; gastric mucosa; ; mucous cell of stomach; ; endothelial cell of lymphatic vessel; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; nucleus;
Biological process	positive regulation of transcription, DNA-templated; positive regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; transcription, DNA-templated; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of transcription, DNA-templated; negative regulation of cell growth;
	Sources:Amigo / QuickGO
Orthologs
	29950
	55942
	ENSG00000197019
	ENSMUSG00000008384
	Q9UHV2; Q53GC0
	Q9JL10
	NM_013376
	NM_018820
	NP_037508; NP_037508.2
	NP_061290
	Wikidata
View/Edit Human	View/Edit Mouse

SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.^[5]^[6]^[7]

Interactions

SERTAD1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197019 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000008384 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Besley GT, Broadhead DM, Lawlor E (Nov 1984). "Acid Esterase Deficiency: Comparison of Biochemical Findings in Infantile and Adult Forms". Organic Acidurias. Vol. 7. pp. 155–6. doi:10.1007/978-94-009-5612-4_52. ISBN 978-94-010-8975-3. PMID 6434876. {{cite book}}: |journal= ignored (help)
^ ^a ^b ^c Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Jan 2000). "Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1". Genes Dev. 13 (22): 3027–33. doi:10.1101/gad.13.22.3027. PMC 317153. PMID 10580009.
^ "Entrez Gene: SERTAD1 SERTA domain containing 1".
^ Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (Jun 2003). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
^ ^a ^b Li J, Melvin WS, Tsai MD, Muscarella P (Apr 2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry. 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.
Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (2004). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM, Guan Sim K, Hsu SI, Bernard HU (2004). "The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1". Virology. 317 (1): 155–64. doi:10.1016/j.virol.2003.08.008. PMID 14675634.
Li J, Melvin WS, Tsai MD, Muscarella P (2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry. 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.
Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD (2006). "Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)". Biochemistry. 44 (40): 13246–56. doi:10.1021/bi0504658. PMID 16201750.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.