SEC24D

SEC24D

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
3EFO, 3EG9

Identifiers

SEC24D, CLCRP2, SEC24 homolog D, COPII coat complex component

External IDs

OMIM: 607186; MGI: 1916858; HomoloGene: 40986; GeneCards: SEC24D; OMA:SEC24D - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q26	Start	118,722,823 bp^[1]
Band	4q26	End	118,838,683 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 G1	Start	123,061,104 bp^[2]
Band	3\|3 G1	End	123,159,290 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

jejunal mucosa

islet of Langerhans

ascending aorta

right coronary artery

Descending thoracic aorta

right lobe of liver

smooth muscle tissue

body of pancreas

tibia

Top expressed in

yolk sac

calvaria

ascending aorta

aortic valve

seminal vesicula

duodenum

epithelium of small intestine

islet of Langerhans

jejunum

umbilical cord

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding SNARE binding zinc ion binding metal ion binding
Cellular component	cytoplasm endoplasmic reticulum membrane membrane Golgi membrane endoplasmic reticulum COPII vesicle coat cytosol ER to Golgi transport vesicle membrane cytoplasmic vesicle
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I in utero embryonic development COPII vesicle coating protein transport intracellular protein transport vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport COPII-coated vesicle cargo loading
Sources:Amigo / QuickGO

Species

Human

Mouse


9871


69608


ENSG00000150961


ENSMUSG00000039234


O94855


n/a

RefSeq (mRNA)


NM_014822 NM_001318066


NM_027135

RefSeq (protein)


NP_001304995 NP_055637


n/a

Location (UCSC)

Chr 4: 118.72 – 118.84 Mb

Chr 3: 123.06 – 123.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150961 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039234 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
^ ^a ^b "Entrez Gene: SEC24D SEC24 related gene family, member D (S. cerevisiae)".

Further reading

Tang BL, Kausalya J, Low DY, et al. (1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem. Biophys. Res. Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Watson P, Forster R, Palmer KJ, et al. (2005). "Coupling of ER exit to microtubules through direct interaction of COPII with dynactin". Nat. Cell Biol. 7 (1): 48–55. doi:10.1038/ncb1206. PMC 1592520. PMID 15580264.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Farhan H, Reiterer V, Korkhov VM, et al. (2007). "Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D". J. Biol. Chem. 282 (10): 7679–89. doi:10.1074/jbc.M609720200. PMID 17210573.

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