PROFILPELAJAR.COM

SD36

SD36
Identifiers
  • [[2-[[(5S,8S,10aR)-8-[[(2S)-5-amino-1-(benzhydrylamino)-1,5-dioxopentan-2-yl]carbamoyl]-3-[8-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]oct-7-ynoyl]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl]-1H-indol-5-yl]-difluoromethyl]phosphonic acid
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC59H62F2N9O12P
Molar mass1158.167 g·mol−1
3D model (JSmol)
  • C1C[C@H](N2[C@H]1CCN(C[C@@H](C2=O)NC(=O)C3=CC4=C(N3)C=CC(=C4)C(F)(F)P(=O)(O)O)C(=O)CCCCCC#CC5=C6CN(C(=O)C6=CC=C5)C7CCC(=O)NC7=O)C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C8=CC=CC=C8)C9=CC=CC=C9
  • InChI=1S/C59H62F2N9O12P/c60-59(61,83(80,81)82)39-21-23-43-38(31-39)32-45(63-43)54(75)65-46-34-68(51(73)20-11-3-1-2-6-13-35-18-12-19-41-42(35)33-69(57(41)78)47-26-28-50(72)66-55(47)76)30-29-40-22-25-48(70(40)58(46)79)56(77)64-44(24-27-49(62)71)53(74)67-52(36-14-7-4-8-15-36)37-16-9-5-10-17-37/h4-5,7-10,12,14-19,21,23,31-32,40,44,46-48,52,63H,1-3,11,20,22,24-30,33-34H2,(H2,62,71)(H,64,77)(H,65,75)(H,67,74)(H,66,72,76)(H2,80,81,82)/t40-,44+,46+,47?,48+/m1/s1
  • Key:JKCSCHXVWPSGBG-OPKPGBGESA-N

SD36 is an experimental anticancer drug which acts as a proteolysis targeting chimera (PROTAC) against the protein STAT3, acting by targeting this protein for destruction by cell maintenance enzymes. It is widely used for research into the treatment of other cancers and the development of related drugs.[1][2][3][4][5][6][7]

See also

References

  1. ^ Bai L, Zhou H, Xu R, Zhao Y, Chinnaswamy K, McEachern D, et al. (November 2019). "A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo". Cancer Cell. 36 (5): 498–511.e17. doi:10.1016/j.ccell.2019.10.002. PMC 6880868. PMID 31715132.
  2. ^ Zhou H, Bai L, Xu R, Zhao Y, Chen J, McEachern D, et al. (December 2019). "Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein". Journal of Medicinal Chemistry. 62 (24): 11280–11300. doi:10.1021/acs.jmedchem.9b01530. PMC 8848307. PMID 31747516.
  3. ^ Kong S, Ge X, Li X, Liu Z, Zhang R, Yang M, et al. (September 2021). "SD-36 promotes growth inhibition and induces apoptosis via suppression of Mcl-1 in glioma". Journal of Cellular and Molecular Medicine. 25 (17): 8261–8270. doi:10.1111/jcmm.16754. PMC 8419162. PMID 34291563.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ^ Gopalsamy A (June 2022). "Selectivity through Targeted Protein Degradation (TPD)". Journal of Medicinal Chemistry. 65 (12): 8113–8126. doi:10.1021/acs.jmedchem.2c00397. PMID 35658428.
  5. ^ Suo Y, Du D, Chen C, Zhu H, Wang X, Song N, et al. (March 2024). "Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3". Journal of Medicinal Chemistry. 67 (6): 4804–4818. doi:10.1021/acs.jmedchem.3c02371. PMID 38466231.
  6. ^ Xu R, Zhou H, Bai L, McEachern D, Wu D, Acharyya RK, et al. (November 2024). "Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression". Journal of Medicinal Chemistry. 67 (22): 20495–20513. doi:10.1021/acs.jmedchem.4c01946. PMC 12981319. PMID 39509603.
  7. ^ Zhou J, Tison K, Zhou H, Bai L, Acharyya RK, McEachern D, et al. (July 2025). "STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity". Nature. 643 (8071): 519–528. Bibcode:2025Natur.643..519Z. doi:10.1038/s41586-025-09000-3. PMC 12240842. PMID 40369063.
Stub icon

This pharmacology-related article is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.