Ruy López may refer to:

• Ruy López de Segura, 16th-century Spanish priest and early chess master
  • Ruy Lopez, one of the oldest and most popular chess openings, named after him, also known as the "Spanish Opening"
• Ruy López de Villalobos, 16th-century Spanish navigator

• Roy Lopez (disambiguation), people with a similar name

This disambiguation page lists articles associated with the title Ruy López.
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