Siddharth alias "Sidhu" comes to New Delhi for his further studies and stays with his sister Esha from Allahabad. His spoiled friend Ganesh trails behind him and arrives later. Sidhu, through perceived destiny and chance, bumps into Janhvi and falls in love with her. Janhvi belongs to a conservative Haryanvi family where her elder brother, Ganpat, is the head and is very protective of his family, mainly his sister, after the loss of their parents.
Initially, Janhvi brushes off Sidhu's constant attempts to be with her in order to keep him safe from Ganpat. An encounter with the goons and Sidhu leads Janhvi to encourage Sidhu to run, but he instead rises to the challenge and fights off all the thugs. While Ganpat goes to threaten Esha and her husband, Sidhu threatens him back viciously as he was one step ahead of him and planned to retaliate (though falsely) by killing Ganpat's family, excluding Janhvi.
Sidhu and Janhvi keep meeting with each other, hiding and running from Janhvi's brother and his men, while Sidhu fights off any thugs that follow him and threaten to hurt him or his family. Eventually, Ganpat decides to use his thugs to beat up a boy who was giving Sidhu a hard time in school, thus giving the impression to the principal of the school that Sidhu is a thug. Sidhu is suspended in return. Then, they hit Esha with a van and frame her husband for him to lose his job all at the same time, while Sidhu and Janhvi agree they should elope and be married before she is married off.
Meanwhile, Ganesh is constantly tricked and goes through various harsh realities about life. In the end, Ganesh loses all his money, his watch, his clothes, his hope to meet his friend Sidhu and a kidney. All his experiences end in the form of making Ganesh accidentally a "Pettycoat Baba", a saint who is believed by the people (not by Ganesh) to be living in the Himalayas for 250 years.
In the climax, Sidhu hatches a plan to bait Ganpat and his men to the wrong area and marry Janhvi with her remaining family members who care for her and Sidhu, until Ganpat gets wind of this and tracks them down. The newlyweds now have to run from a mass of thugs. This leads to a final battle which ends with a one-on-one fight with Sidhu and Ganpat. Sidhu wins and refuses to deal with the death blow, allowing him to live. Ganpat allows Janhvi and Sidhu to leave, finally accepting him as his brother in-law. Sidhu and Janhvi leave and get married.
Taran Adarsh of IndiaFM gave the film 1 out of 5, writing, "On the whole, RUN is too weak a fare to leave any impact whatsoever."[5]Kaveree Bamzai of India Today wrote, "For some reason Mumbai filmmakers, living in their plush, Lalique-studded Juhu bungalows, assume that small-town Indians love to see themselves ridiculed onscreen. That is the only reason why Boney Kapoor would produce a film like Run, ostensibly an action movie aimed at what is known in Bollyspeak as B-class towns. Clearly, Kapoor has not heard of the rampant glocalisation of India that economic liberalisation and satellite television have wrought."[6]
^"Bhoomika runs for Abhishek!". Rediff. Archived from the original on 29 May 2022. Retrieved 13 October 2020. - Taran Adarsh (14 May 2004). "Run Review". Bollywood Hungama. Archived from the original on 29 May 2022. Retrieved 14 May 2020.
^Ronjita Kulkarni (14 May 2004). "Run for Abhishek!". Rediff. Archived from the original on 16 July 2014. Retrieved 23 February 2020.