Sir Roy Yorke CalneFRSFRCS (30 December 1930 – 6 January 2024) was a British surgeon and pioneer in organ transplantation. He was part of the team that performed the first liver transplantation operation in Europe in 1968, the world's first liver, heart and lung transplantation in 1987, the first intestinal transplant in the UK in 1992 and the first successful combined stomach, intestine, pancreas, liver and kidney cluster transplantation in 1994.
In 1960, Calne showed that 6-mercaptopurine (6-MP) could prolong the survival of a transplanted kidney in a dog, and later showed that azathioprine was more effective. Through the mid-1960s, he worked to develop solutions in surgical techniques and organ rejection. In the late 1970s, he began to experiment with the immunosuppressant ciclosporin A, which was then introduced into regular use to prevent organ rejection.
Roy Calne was born in Richmond, Surrey on 30 December 1930, to Joseph, a car engineer, and his wife Eileen (née Gubbay).[1] He was the elder of two sons; his younger brother Donald later became a neurologist in Canada.[1] Roy was educated at Dulwich Prep London and then Lancing College.[1][2] Twice, he was evacuated to Ludlow, Shropshire.[1] He gained his place at Guy's Hospital at the age of 16 years.[1] There, he completed his medical education in 1952.[3] For his national service, he served in the Royal Army Medical Corps between 1953 and 1955, being stationed with the Gurkhas.[1][3] When he returned to England he took up a post teaching anatomy at Oxford University.[1][3]
Early career
In the late 1950s, with the encouragement of urologist John Hopewell and professor of physiology David Slome, and while a surgical trainee at the Royal Free Hospital, Calne worked at the Royal College of Surgeon's Buckston Browne Farm.[4][5] After unsuccessful attempts at rat kidney grafts, he repeated the dog experiments of Jim Dempster and confirmed his findings of unsuccessful survival of kidneys with lethal doses of radiation.[5] Calne then showed that 6-mercaptopurine (6-MP) could prolong the survival of a transplanted kidney in a dog.[4][5] The findings were published in his landmark paper in February 1960 in The Lancet.[2][5] He performed two unsuccessful human kidney transplants using 6-MP in 1960, and one the previous year.[5]
Encouraged by Peter Medawar, Calne then earned a Harkness Fellowship to study 6-MP with dog transplant work at Harvard's Peter Bent Brigham Hospital with Joseph Murray and Francis Moore.[4][5] After obtaining azathioprine, then known as BW57-322, from the Burroughs Wellcome Research Laboratories, Calne and Murray, in 1961, showed, in the first transplant using that drug, that it was a more effective immunosuppressant than 6-MP at prolonging the survival of transplanted kidneys in dogs.[2][6] When either of these drugs were used in humans, survival rates remained low, and by 1963, Calne doubted successful transplantation.[6] Two years earlier, he had taken a job at St Mary's Hospital.[1] In 1964, Calne visited Tulane University, New Orleans, to learn of Keith Reemtsma's experiences with transplanting kidneys from chimpanzees, and persuaded London Zoo to assist when he returned to England.[7] Through the mid-1960s, he worked to develop solutions in surgical techniques and organ rejection.[3] In 1965 at Cambridge, he was appointed professor and chair of surgery, and teamed up with King's College liver specialist Roger Williams.[2][8] Calne then performed the first liver transplantation operation in Europe in 1968.[9]
In the late 1970s, with the help of the Agricultural Research Institute of Animal Physiology at Babraham, Calne worked on liver transplantation in pigs and began to experiment with the immunosuppressant ciclosporin A.[9][10] By 1978, it was being used to prevent organ rejection in transplant operations.[11]
Later career
Calne performed the world's first liver, heart and lung transplantation with John Wallwork in 1987,[12][13] the first intestinal transplant in the UK in 1992 and the first successful combined stomach, intestine, pancreas, liver and kidney cluster transplantion in 1994.[14] In 1995, he stated that xenotransplantation "is just around the corner, but it may be a very long corner."[15]
Calne enjoyed drawing and painting from an early age. At school he was taught and encouraged by an art teacher Francis Russell Flint, son of the Scottish artist William Russell Flint. As a medical student in London he would regularly visit art galleries to copy the works of great masters.[18] In 1988 he performed a liver transplant on the Scottish painter John Bellany, who began to paint self-portraits while still in intensive care and had completed 60 during his hospital stay. Bellany gave Calne painting lessons and the two became friends, painting portraits of each other. One of his portraits of Bellany was exhibited by the Royal Academy.[18] Calne went on to paint some transplant patients, believing that it brought closeness and humanity to the surgeon-patient relationship, especially with children. An exhibition of his paintings entitled The Gift of Life was displayed at the Barbican in 1991.[3] Other exhibitions of his artwork have intended to promote awareness of transplantation.[1]
Ellis, Harold, 1926–, Calne, Roy Y. (Roy Yorke), Sir, 1930– and Christopher Watson (2011) Lecture notes on general surgery (Twelfth edition). Oxford : Wiley Blackwell. ISBN978-1-4443-3440-1.
Calne, Roy Y. (Roy Yorke), Sir, 1930– (1970) A Gift of Life: Observations on Organ Transplantation. New York : Basic Books. ISBN0-465-02675-3, ISBN978-0-465-02675-3
Calne, Roy Y. (Roy Yorke), Sir, 1930– (1996) Art, Surgery and Transplantation. London : Williams & Wilkins Europe. ISBN0-683-23094-8, ISBN978-0-683-23094-9
