It was erected a first time on 1561.06.21 as Diocese of Verapaz, on territory split off from the then Roman Catholic Diocese of Guatemala, as a suffragan of the Metropolitan Mexico, but was suppressed on 1603.06.23.
It was restored on 27 July 1921 albeit demoted, as the Apostolic Vicariate of Verapaz and Petén, on territory split off from the meanwhile Metropolitan Archdiocese of Guatemala, a missionary pre-diocesan jurisdiction, exempt (directly subject to the Holy See, not yet part of an ecclesiastical province).
On 14 January 1935, it was promoted as Diocese of Vera Paz, also known after its see as Diocese of Cobán.
On 1951.03.10, it lost territory to establish the then Apostolic Administration of El Petén.
Luis Durou y Sure, Lazarists (C.M.), Apostolic Administrator 1928.11.12 – 1935.01.14), while Metropolitan Archbishop of Guatemala (Guatemala) (1928.06.30 – 1938.12.17)
Juan José Gerardi Conedera (1967.05.05 – 1974.08.22), also President of Episcopal Conference of Guatemala (1972–1978); later Bishop of Santa Cruz del Quiché (Guatemala) (1974.08.22 – 1984.08.14), President of Episcopal Conference of Guatemala (1980–1982), Titular Bishop of Guardialfiera (1984.08.14 – 1998.04.26) & Auxiliary Bishop of Guatemala (Guatemala) (1984.08.14 – 1998.04.26)
Rodolfo Valenzuela Núñez (2001.02.22 – ...), also President of Episcopal Conference of Guatemala (2012.03 – ...); succeeding as former Coadjutor Bishop of Vera Paz (1997.02.19 – 2001.02.22)