Myers was selected by the Chicago Cubs in the Rule 5 Draft in 1996 and spent the entire season in the Cubs major league bullpen. He alternated between the Cubs and their triple A team (Iowa Cubs) from 1997–1999 and then was traded to the San Diego Padres for Gary Matthews Jr.
Myers pitched for the Padres from 2000–2002 and then for the Los Angeles Dodgers for two seasons. After being released in midseason in 2004, he signed with the Hanshin Tigers in Japan, where he finished the season. After playing independent league ball in 2005, Myers retired from baseball.