Uihlein joined the family business, Joseph Schlitz Brewing Company, full-time in the sales staff department, in 1942.[2] He became vice president in 1945, vice president of sales in 1951, Executive Vice President in 1959, and company President in 1961.[2] In 1967, he became chairman of the board of directors.[2] He served on the board of directors of the United States Brewers' Association.[2] He was one of the four leading men in the Milwaukee Brewers, Inc. along with Allan "Bud" Selig, Judge Robert C. Cannon and Edmund Fitzgerald to bring the Seattle Pilots baseball team to Milwaukee in April 1970.
Uihlein died from complications of leukemia on November 12, 1976.[1][2] His sons, Robin and James Uihlein, play polo at the Sarasota Polo Club in Sarasota, Florida.[6] His family owns the Schroeder-Manatee Ranch, which comprises Lakewood Ranch, Florida, the Sarasota Polo Club, and the Lakewood Ranch Golf & Country Club.[6][7]