Recombinant human tissue kallikrein-1
Recombinant human tissue kallikrein-1 , also known as DM199, is an experimental drug that acts on the kallikrein-kinin system and is developed for diabetes.[ 1] [ 2] [ 3] [ 4]
References
^ Maneva-Radicheva, Lilia; Amatya, Christina; Parker, Camille; Ellefson, Jacob; Radichev, Ilian; Raghavan, Arvind; Charles, Matthew L.; Williams, Mark S.; Robbins, Mark S.; Savinov, Alexei Y. (26 September 2014). "Autoimmune Diabetes Is Suppressed by Treatment with Recombinant Human Tissue Kallikrein-1" . PLOS ONE . 9 (9): e107213. Bibcode :2014PLoSO...9j7213M . doi :10.1371/journal.pone.0107213 PMC 4178025 PMID 25259810 . ^ Charest-Morin, Xavier; Raghavan, Arvind; Charles, Matthew L.; Kolodka, Tadeusz; Bouthillier, Johanne; Jean, Mélissa; Robbins, Mark S.; Marceau, François (March 2015). "Pharmacological effects of recombinant human tissue kallikrein on bradykinin B 2 receptors" . Pharmacology Research & Perspectives . 3 (2): e00119. doi :10.1002/prp2.119 PMC 4448978 PMID 26038695 . ^ Kolodka, Tadeusz; Charles, Matthew L.; Raghavan, Arvind; Radichev, Ilian A.; Amatya, Christina; Ellefson, Jacob; Savinov, Alexei Y.; Nag, Abhijeet; Williams, Mark S.; Robbins, Mark S. (6 August 2014). "Preclinical Characterization of Recombinant Human Tissue Kallikrein-1 as a Novel Treatment for Type 2 Diabetes Mellitus" . PLOS ONE . 9 (8): e103981. Bibcode :2014PLoSO...9j3981K . doi :10.1371/journal.pone.0103981 PMC 4123992 PMID 25100328 . ^ Alexander-Curtis, Michelle; Pauls, Rick; Chao, Julie; Volpi, John J; Bath, Philip M; Verdoorn, Todd A. (January 2019). "Human tissue kallikrein in the treatment of acute ischemic stroke" . Therapeutic Advances in Neurological Disorders . 12 : 175628641882191. doi :10.1177/1756286418821918 PMC 6348491 PMID 30719079 .
