Shortly after training, Bono saw duty in Operations Desert Shield and Desert Storm as head, Casualty Receiving, Fleet Hospital Five in Saudi Arabia from August 1990 to March 1991. Upon returning, she was stationed at Naval Medical Center Portsmouth as a surgeon in the General Surgery department; surgical intensivist in the Medical/Surgical Intensive Care Unit, and attending surgeon at the Burn Trauma Unit at Sentara Norfolk General Hospital. Her various appointed duties included division head of Trauma; head of the Ambulatory Procedures Department (APD); chair of the Laboratory Animal Care and Use Committee; assistant head of the Clinical Investigations and Research department; chair of the Medical Records Committee, and Command Intern Coordinator. She has also been as the Specialty Leader for Intern Matters to the Surgeon General of the Navy.[6]
In September 1999, she was assigned as the director of Restorative Care at the National Naval Medical Center in Bethesda, Maryland, followed by assignment to the Bureau of Medicine and Surgery from September 2001 to December 2002 as the medical corps career planning officer for the Chief of the Medical Corps. She returned to the National Naval Medical Center in January 2003 as director for Medical–Surgical Services.[6]
From August 2004 through August 2005 she was the executive assistant to the 35th Navy Surgeon General of the Navy and Chief, Bureau of Medicine and Surgery. Following that, she reported to Naval Hospital Jacksonville, Florida, as the commanding officer from August 2005 to August 2008. In September 2008, she became the chief of staff, deputy director Tricare Management Activity (TMA) of the Office of the Assistant Secretary of Defense, Health Affairs (OASD(HA)). She reported as deputy director, Medical Resources, Plans and Policy (N093), Chief of Naval Operations in June 2010.
On March 22, 2020, Bono was named by Washington State Governor Jay Inslee to lead the state health system's response to the 2020 coronavirus pandemic.[2]
