Manjaly was born on 7 February 1958 in Kerala, India, to Kathreena and M.V. Chacko.[4] He received his primary education at St. Francis Xavier School, Vendore, Kerala and completed his high school from Tyagarajar High School, Alagappanagar, Trichur, Kerala. He joined St. Lawrence Minor Seminary, Agra, in 1973 and completed it in year 1975. He joined St. Joseph's Regional Seminary, Allahabad, in 1975 and completed his philosophy and theology education in year 1983. He completed his graduation and post graduation from Agra University. He completed his doctorate in spirituality from Angelicum University, Rome.[5]
Manjaly was appointed bishop of Varanasi on 24 February 2007 and consecrated on 30 April 2007. He was appointed bishop of Allahabad on 17 October 2013 and installed on 3 December 2013.[6][7] He was appointed Archbishop of Agra on 12 November 2020 and installed on 7 January 2021.