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RNPS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4A8X
Identifiers
Aliases	RNPS1, E5.1, RNA binding protein with serine rich domain 1
External IDs	OMIM: 606447; MGI: 97960; HomoloGene: 40648; GeneCards: RNPS1; OMA:RNPS1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	2,268,397 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	24,644,875 bp
RNA expression pattern
	Top expressed in
	gonad; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; right frontal lobe; ; ganglionic eminence; ; paraflocculus of cerebellum; ; anterior cingulate cortex; ; ventricular zone; ; gastrocnemius muscle; ; Brodmann area 10;
	Top expressed in
	tail of embryo; ; genital tubercle; ; ventricular zone; ; embryo; ; zygote; ; yolk sac; ; embryo; ; neural layer of retina; ; morula; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	mRNA 3'-UTR binding; protein binding; RNA binding; nucleic acid binding;
Cellular component	cytoplasm; cytosol; nuclear speck; exon-exon junction complex; nucleoplasm; ASAP complex; nucleus;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; regulation of alternative mRNA splicing, via spliceosome; mRNA export from nucleus; transcription, DNA-templated; negative regulation of mRNA splicing, via spliceosome; RNA splicing; positive regulation of apoptotic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA 3'-end processing; RNA export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
	10921
	19826
	ENSG00000205937
	ENSMUSG00000034681
	Q15287
	Q99M28
	NM_001286625; NM_001286626; NM_001286627; NM_006711; NM_080594
	NM_001080127; NM_001080128; NM_009070; NM_001357626
	NP_001273554; NP_001273555; NP_001273556; NP_006702; NP_542161
	NP_001073596; NP_001073597; NP_033096; NP_001344555
	Wikidata
View/Edit Human	View/Edit Mouse

RNA-binding protein with serine-rich domain 1 is a protein that in humans is encoded by the RNPS1 gene.^[5]^[6]^[7]

Function

This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. This protein contains many serine residues. Two splice variants have been found for this gene; both variants encode the same protein.^[7]

Interactions

RNPS1 has been shown to interact with SART3^[8] and Pinin.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205937 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Loyer P, Trembley JH, Lahti JM, Kidd VJ (Jun 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 ( Pt 11) (11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.
^ Badolato J, Gardiner E, Morrison N, Eisman J (Dec 1995). "Identification and characterisation of a novel human RNA-binding protein". Gene. 166 (2): 323–7. doi:10.1016/0378-1119(95)00571-4. PMID 8543184.
^ ^a ^b "Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain".
^ Harada K, Yamada A, Yang D, Itoh K, Shichijo S (Sep 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.
^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
^ Li C, Lin RI, Lai MC, Ouyang P, Tarn WY (Oct 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Molecular and Cellular Biology. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.

External links

Overview of all the structural information available in the PDB for UniProt: Q15287 (RNA-binding protein with serine-rich domain 1) at the PDBe-KB.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205937 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034681 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9580558-5] Loyer P, Trembley JH, Lahti JM, Kidd VJ (Jun 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 ( Pt 11) (11): 1495–506. doi:10.1242/jcs.111.11.1495. PMID 9580558.

[pmid8543184-6] Badolato J, Gardiner E, Morrison N, Eisman J (Dec 1995). "Identification and characterisation of a novel human RNA-binding protein". Gene. 166 (2): 323–7. doi:10.1016/0378-1119(95)00571-4. PMID 8543184.

[entrez-7] "Entrez Gene: RNPS1 RNA binding protein S1, serine-rich domain".

[pmid11477570-8] Harada K, Yamada A, Yang D, Itoh K, Shichijo S (Sep 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570. S2CID 24724555.

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid14517304-10] Li C, Lin RI, Lai MC, Ouyang P, Tarn WY (Oct 2003). "Nuclear Pnn/DRS protein binds to spliced mRNPs and participates in mRNA processing and export via interaction with RNPS1". Molecular and Cellular Biology. 23 (20): 7363–76. doi:10.1128/MCB.23.20.7363-7376.2003. PMC 230327. PMID 14517304.

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RNPS1

Function

Interactions

References

Further reading

External links