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RBMX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MB0, 2MKS
Identifiers
Aliases	RBMX, HNRNPG, HNRPG, RBMXP1, RBMXRT, RNMX, hnRNP-G, MRXS11, RNA binding motif protein, X-linked, RNA binding motif protein X-linked
External IDs	OMIM: 300199; MGI: 1343044; HomoloGene: 20494; GeneCards: RBMX; OMA:RBMX - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	136,880,764 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	56,438,396 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; left ovary; ; Achilles tendon; ; right ovary; ; canal of the cervix; ; smooth muscle tissue; ; body of uterus; ; mucosa of ileum; ; rectum;
	Top expressed in
	saccule; ; genital tubercle; ; Rostral migratory stream; ; ventricular zone; ; ganglionic eminence; ; tail of embryo; ; otic vesicle; ; otic placode; ; neural layer of retina; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; nucleic acid binding; mRNA binding; RNA binding; chromatin binding; protein domain specific binding; identical protein binding; single-stranded RNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding;
Cellular component	catalytic step 2 spliceosome; membrane; supraspliceosomal complex; nucleoplasm; spliceosomal complex; extracellular exosome; nucleus; extracellular space; ribonucleoprotein complex;
Biological process	mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; mRNA processing; transcription by RNA polymerase II; regulation of alternative mRNA splicing, via spliceosome; transcription, DNA-templated; negative regulation of mRNA splicing, via spliceosome; membrane protein ectodomain proteolysis; osteoblast differentiation; cellular response to interleukin-1; protein homooligomerization; RNA splicing; positive regulation of transcription by RNA polymerase II; RNA metabolic process; protein complex oligomerization; mRNA splice site selection; positive regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	27316
	19655
	ENSG00000147274
	ENSMUSG00000031134
	P38159
	Q9WV02
	NM_001164803; NM_002139
	NM_001166623; NM_011252
	NP_001158275; NP_002130
	NP_001160095; NP_035382
	Wikidata
View/Edit Human	View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.^[5]^[6]^[7]

Function

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.^[7]

Interactions

RBMX has been shown to interact with SFRS10^[8] and CDC5L.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147274 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031134 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Delbridge ML, Lingenfelter PA, Disteche CM, Graves JA (Jul 1999). "The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome". Nature Genetics. 22 (3): 223–4. doi:10.1038/10279. PMID 10391206. S2CID 43301464.
^ Mazeyrat S, Saut N, Mattei MG, Mitchell MJ (Jul 1999). "RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene". Nature Genetics. 22 (3): 224–6. doi:10.1038/10282. PMID 10391207. S2CID 13071214.
^ ^a ^b "Entrez Gene: RBMX RNA binding motif protein, X-linked".
^ Hofmann Y, Wirth B (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Human Molecular Genetics. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. PMID 12165565.
^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

Le Coniat M, Soulard M, Della Valle V, Larsen CJ, Berger R (Mar 1992). "Localization of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein G (hnRNP-G) to chromosome 6p12". Human Genetics. 88 (5): 593–5. doi:10.1007/bf00219352. PMID 1551662. S2CID 23980780.
Soulard M, Della Valle V, Siomi MC, Piñol-Roma S, Codogno P, Bauvy C, Bellini M, Lacroix JC, Monod G, Dreyfuss G (Sep 1993). "hnRNP G: sequence and characterization of a glycosylated RNA-binding protein". Nucleic Acids Research. 21 (18): 4210–7. doi:10.1093/nar/21.18.4210. PMC 310052. PMID 7692398.
Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (Jun 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Human Molecular Genetics. 8 (6): 959–69. doi:10.1093/hmg/8.6.959. PMID 10332027.
Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC (Mar 2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Human Molecular Genetics. 9 (5): 685–94. doi:10.1093/hmg/9.5.685. PMID 10749975.
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Lingenfelter PA, Delbridge ML, Thomas S, Hoekstra HE, Mitchell MJ, Graves JA, Disteche CM (Jul 2001). "Expression and conservation of processed copies of the RBMX gene". Mammalian Genome. 12 (7): 538–45. CiteSeerX 10.1.1.721.2504. doi:10.1007/s00335001-0003-z. PMID 11420617. S2CID 7201204.
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Hofmann Y, Wirth B (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Human Molecular Genetics. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. PMID 12165565.
Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, Shabanowitz J, Hunt DF, Greenough WT (Oct 2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". The Journal of Neuroscience. 22 (20): 8827–37. doi:10.1523/JNEUROSCI.22-20-08827.2002. PMC 6757688. PMID 12388589.
Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (Nov 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry" (PDF). Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ong SE, Mittler G, Mann M (Nov 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174. S2CID 6654604.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147274 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031134 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10391206-5] Delbridge ML, Lingenfelter PA, Disteche CM, Graves JA (Jul 1999). "The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome". Nature Genetics. 22 (3): 223–4. doi:10.1038/10279. PMID 10391206. S2CID 43301464.

[pmid10391207-6] Mazeyrat S, Saut N, Mattei MG, Mitchell MJ (Jul 1999). "RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene". Nature Genetics. 22 (3): 224–6. doi:10.1038/10282. PMID 10391207. S2CID 13071214.

[entrez-7] "Entrez Gene: RBMX RNA binding motif protein, X-linked".

[pmid12165565-8] Hofmann Y, Wirth B (Aug 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Human Molecular Genetics. 11 (17): 2037–49. doi:10.1093/hmg/11.17.2037. PMID 12165565.

[pmid11101529-9] Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.

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RBMX

Function

Interactions

References

Further reading