RAP2A
Protein-coding gene in the species Homo sapiens
Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene .[ 5] Ras-related protein family.
Interactions
RAP2A has been shown to interact with RUNDC3A ,[ 6] RASSF5 [ 7] RALGDS .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000125249 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051615 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family" .^ Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2" . European Journal of Biochemistry . 252 (2): 290– 8. doi :10.1046/j.1432-1327.1998.2520290.x PMID 9523700 . ^ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene . 21 (9): 1381– 90. doi :10.1038/sj.onc.1205192 . PMID 11857081 . S2CID 240243 . ^ Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2" . The Journal of Biological Chemistry . 274 (13): 8737– 45. doi :10.1074/jbc.274.13.8737 PMID 10085114 .
Further reading
Lerosey I, Chardin P, de Gunzburg J, Tavitian A (Mar 1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis" . The Journal of Biological Chemistry . 266 (7): 4315– 21. doi :10.1016/S0021-9258(20)64324-1 PMID 1900290 . Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (Aug 1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene . 3 (2): 201– 4. PMID 3045729 . Farrell FX, Yamamoto K, Lapetina EG (Jan 1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated" . The Biochemical Journal . 289 ( Pt 2) (Pt 2): 349– 55. doi :10.1042/bj2890349 . PMC 1132174 PMID 8424780 . Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I (Sep 1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS" . The EMBO Journal . 16 (18): 5582– 91. doi :10.1093/emboj/16.18.5582 . PMC 1170190 PMID 9312017 . Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2" . European Journal of Biochemistry . 252 (2): 290– 8. doi :10.1046/j.1432-1327.1998.2520290.x PMID 9523700 . Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2" . The Journal of Biological Chemistry . 274 (13): 8737– 45. doi :10.1074/jbc.274.13.8737 PMID 10085114 . Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (May 1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily" . The Journal of Biological Chemistry . 274 (19): 13556– 62. doi :10.1074/jbc.274.19.13556 PMID 10224125 . Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP" . Proteins . 37 (3): 465– 73. doi :10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O PMID 10591105 . de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (Jul 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs" . The Journal of Biological Chemistry . 275 (27): 20829– 36. doi :10.1074/jbc.M001113200 PMID 10777494 . Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience . 3 (7): 661– 9. doi :10.1038/76615 . hdl :1842/742 PMID 10862698 . S2CID 14392630 . Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD (Aug 2000). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao" . The Biochemical Journal . 350 Pt 1 (Pt 1): 19– 29. doi :10.1042/0264-6021:3500019 . PMC 1221220 PMID 10926822 . Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras" . The Journal of Biological Chemistry . 276 (45): 42219– 25. doi :10.1074/jbc.M105760200 PMID 11524421 . Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene . 21 (9): 1381– 90. doi :10.1038/sj.onc.1205192 . PMID 11857081 . S2CID 240243 . Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (Nov 2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene . 21 (53): 8105– 13. doi :10.1038/sj.onc.1206003 . PMID 12444546 . S2CID 13499744 . Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ (Feb 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1593 (2– 3): 141– 9. doi :10.1016/S0167-4889(02)00365-8 . PMID 12581858 . Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (Apr 2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase" . The Journal of Biological Chemistry . 279 (16): 15711– 4. doi :10.1074/jbc.C300542200 PMID 14966141 . Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization" . The Journal of Biological Chemistry . 279 (21): 22353– 61. doi :10.1074/jbc.M312867200 PMID 15031288 .
PDB gallery
1kao : CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAP2A WITH GDP
2rap : THE SMALL G PROTEIN RAP2A IN COMPLEX WITH GTP
3rap : The small G protein Rap2 in a non catalytic complex with GTP
