R1162-like plasmid antisense RNA

R1162-like plasmid antisense RNA
Predicted secondary structure and sequence conservation of Plasmid_R1162
Identifiers
SymbolPlasmid_R1162
RfamRF00043
Other data
RNA typeGene; antisense
Domain(s)Bacteria
SOSO:0001263
PDB structuresPDBe

R1162-like plasmid antisense RNA is a 75-base RNA molecule which negatively regulates the RepI region of the plasmid.[1] The protein product of this gene region, along with another protein, controls the copy number of the 8.75kB R1162 plasmid.[2]

Experimental evidence has shown that in Escherichia coli, when levels of this RNA are decreased, the plasmid copy number of R1162 is increased.[1]

References

  1. ^ a b Kim K, Meyer RJ (October 1986). "Copy-number of broad host-range plasmid R1162 is regulated by a small RNA". Nucleic Acids Research. 14 (20): 8027–8046. doi:10.1093/nar/14.20.8027. PMC 311832. PMID 2430262.
  2. ^ Kim K, Meyer RJ (October 1985). "Copy number of the broad host-range plasmid R1162 is determined by the amounts of essential plasmid-encoded proteins". Journal of Molecular Biology. 185 (4): 755–767. doi:10.1016/0022-2836(85)90060-9. PMID 2932556.
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