She is best known for her expertise on truth commissions and transitional justice, and has focused her work on official truth-seeking measures in political transitions around the world.[2]
Hayner has worked as a consultant at the Ford Foundation and the Office of the United Nations High Commissioner for Human Rights. She also served as a program officer for the Joyce Mertz-Gilmore Foundation, where she focused on international human rights and global security.
Hayner has written widely on the subject of truth-seeking. In 2001 she published the book Unspeakable Truths: Confronting State Terror and Atrocity, examining the work of over 20 truth commissions worldwide.