The Primera División de Fútbol Profesional Apertura 1999 season (officially "Copa Pilsener Apertura 1999") started on August 28, 1999, and finished on December 26, 1999.
The season saw Águila win its 12th league title after a 1-0 victory over Municipal Limeno in the final.
Key note
After round 8 of this season, Árabe Marte reverted to their historic name of Atlético Marte.