Polysaccharide–protein conjugate

Polysaccharide–protein conjugates may have better solubility and stability, reduced immunogenicity, prolonged circulation time, and enhanced targeting ability compared to native protein.[1] They are promising alternatives to PEG–protein drugs, in which non-biodegradable high molecular weight PEG causes health concerns.[2]

Synthetic methods

Reductive amination, the Maillard reaction, EDC/NHS coupling, DMTMM coupling, disulfide bond formation, and click chemistry are common methods to synthesize polysaccharide–protein conjugates.[1]

Applications

Polysaccharide–protein conjugates are used for food industry, vaccines, and drug delivery systems.[3][4][5][6]

References

  1. ^ a b Zhou, Yang; Petrova, Stella P.; Edgar, Kevin J. (2021-11-15). "Chemical synthesis of polysaccharide–protein and polysaccharide–peptide conjugates: A review". Carbohydrate Polymers. 274: 118662. doi:10.1016/j.carbpol.2021.118662. ISSN 0144-8617. PMID 34702481. S2CID 239999294.
  2. ^ Baumann, Andreas; Tuerck, Dietrich; Prabhu, Saileta; Dickmann, Leslie; Sims, Jennifer (2014-10-01). "Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?". Drug Discovery Today. 19 (10): 1623–1631. doi:10.1016/j.drudis.2014.06.002. ISSN 1359-6446. PMID 24929223.
  3. ^ Akhtar, Mahmood; Dickinson, Eric (2007-06-01). "Whey protein–maltodextrin conjugates as emulsifying agents: An alternative to gum arabic". Food Hydrocolloids. 21 (4): 607–616. doi:10.1016/j.foodhyd.2005.07.014. ISSN 0268-005X.
  4. ^ Perciani, Catia T.; Barazzone, Giovana C.; Goulart, Cibelly; Carvalho, Eneas; Cabrera-Crespo, Joaquin; Gonçalves, Viviane M.; Leite, Luciana C. C.; Tanizaki, Martha M. (2013-06-01). "Conjugation of Polysaccharide 6B from Streptococcus pneumoniae with Pneumococcal Surface Protein A: PspA Conformation and Its Effect on the Immune Response". Clinical and Vaccine Immunology. 20 (6): 858–866. doi:10.1128/CVI.00754-12. PMC 3675967. PMID 23554468.
  5. ^ Luo, Yanan; Wang, Xuenv; Du, Dan; Lin, Yuehe (2015-09-15). "Hyaluronic acid-conjugated apoferritin nanocages for lung cancer targeted drug delivery". Biomaterials Science. 3 (10): 1386–1394. doi:10.1039/C5BM00067J. ISSN 2047-4849. PMID 26301700.
  6. ^ Frasch, Carl E. (2009-10-30). "Preparation of bacterial polysaccharide-protein conjugates: analytical and manufacturing challenges". Vaccine. 27 (46): 6468–6470. doi:10.1016/j.vaccine.2009.06.013. ISSN 1873-2518. PMID 19555714.


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