Polycomb repressive complex 1
Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. Polycomb-group proteins play a major role in transcriptional regulation during development. Polycomb Repressive Complexes PRC1 and PRC2 function in the silencing of expression of the Hox gene network involved in development as well as the inactivation of the X chromosome.[1] PRC1 inhibits the activated form of RNA polymerase II preinitiation complex with the use of H3K27me. PRC1 binds to three nucleosomes, this is believed to limit access of transcription factors to the chromatin, and therefore limit gene expression.[2]
References
- ^ Plath, Kathrin; Fang, Jia; Mlynarczyk-Evans, Susanna K.; Cao, Ru; Worringer, Kathleen A.; Wang, Hengbin; Cruz, Cecile C. de la; Otte, Arie P.; Panning, Barbara (2003-04-04). "Role of Histone H3 Lysine 27 Methylation in X Inactivation". Science. 300 (5616): 131–135. Bibcode:2003Sci...300..131P. doi:10.1126/science.1084274. ISSN 0036-8075. PMID 12649488. S2CID 28578313.
- ^ Lehmann, Lynn; Ferrari, Roberto; Vashisht, Ajay A.; Wohlschlegel, James A.; Kurdistani, Siavash K.; Carey, Michael (2012-10-19). "Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes". Journal of Biological Chemistry. 287 (43): 35784–35794. doi:10.1074/jbc.M112.397430. ISSN 0021-9258. PMC 3476247. PMID 22910904.
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