Paula (Natasha Dupeyrón) prepares to give an anniversary surprise to her boyfriend Chema, a famous telenovela actor. But the surprise is hers, however, when she finds him cheating on her with his agent Marcelo (David Alegre). Paula, in the company of her friends Fernanda (María Gabriela de Faría) and Jennifer (Stephanie Gerard), comes to the conclusion that what she needs to get rid of disappointment is a virgin man who will surely value her. The three friends come up with Plan V (virgin), that introduces them in the fascinating and, until then, unknown world of the university, in which they will find a series of endearing characters, among them Luis (José Pablo Minor), a handsome and intelligent virgin that will change their lives.