For thousands of years, the Sound was home to the Calusa Indians and their ancestors. The 67-acre Pineland Archeological District faces the Sound on the western shore of Pine Island. The Pineland site features several shell mounds, including a burial mound.[3] The Mark Pardo Shellworks Site is on Cayo Costa Island, on the east side of the sound. Useppa Island, in the northern part of the sound, has a long history of occupation documented by archaeologists.[4] In the 18th and 19th centuries Pine Island Sound was the site of seasonal camps used by Cubans catching fish for the Havana market.[5]
The Sound is also centerpiece of the Great Calusa Blueway paddling trail, a 190-mile canoe and kayak trail.