Kieran Crowley selected Pierre Bruno also for the 2022 Six Nations Championship, but his debut in the tournament[13] against Ireland was unfortunate, as he had to be replaced after only 20 minutes due to a controversial refereeing decision.[14] Bruno was also in the Italian starting team that faced Scotland in Rome. The match ended in another defeat for Italy (22-33), but with signs of improvement.[15]
Bruno had the opportunity to make up for it in November 2022 Autumn internationals, when he scored two tries in the sparkling victory of Italy over Samoa (49-17),[16] and another try against Australia, a first ever win for the Italian team facing the Wallabies (28-27).[17]