Pick of Destiny may refer to:

• Tenacious D in The Pick of Destiny, a comedy/rock musical set in the 1990s, starring Tenacious D
• The Pick of Destiny, album by the American hard rock band Tenacious D, serving as the soundtrack of the movie "Tenacious D in The Pick of Destiny"
• POD (song), a song from the album "The Pick of Destiny"

This disambiguation page lists articles associated with the title Pick of Destiny.
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