Phosphopeptide

Phosphopeptides are modified self antigens which may induce an immune response.

Protein phosphorylation is a very important and frequent post-translational modification that can impact a protein's localization, stability, and whether or not it can dimerize or form stable bonds with other substances. It is vital to pinpoint which amino acid in the protein’s primary structure is being phosphorylated in order to understand the functions of a phosphopeptide. This is accomplished through phosphopeptide mapping, which involves digestion of a radioactively labeled protein, separation of phosphopeptide products, and finally analysis via high-performance liquid chromatography (HPLC) or mass spectrometry. Analysis of phosphopeptides can provide information about which amino acids are phosphorylated and how many sites on the primary sequence are phosphorylated.[1]

Phosphorylation of serine and threonine residues is conserved during MHC class I and MHC class II antigen processing. Phosphopeptides are thus displayed on the surface of cells. As modified self antigens, they are potentially immunogenic when compared to unmodified self proteins as the immune cells (T-cells) which recognise them are possibly not subject to central tolerance mechanisms. This may contribute to the potential capability of phosophopeptides to serve as tumor antigens in the treatment of colorectal cancer.[2]

References

  1. ^ Meisenhelder, Jill; Hunter, Tony; Geer, Peter (December 1999). "Phosphopeptide Mapping and Identification of Phosphorylation Sites". Current Protocols in Protein Science. 18 (1): Unit13.9. doi:10.1002/0471140864.ps1309s18. ISSN 1934-3655. PMID 18429120. S2CID 9052924.
  2. ^ Penny, S; Abelin, J; Saeed, A; Malaker, S; Trantham, P; Shabanowitz, J; Ward, S; Hunt, D; Cobbold, M (2016). "Phosphopeptides as novel tumour antigens in colorectal cancer". European Journal of Cancer. 61: S213. doi:10.1016/S0959-8049(16)61751-3.

Read other articles:

Daytona 500 2012

Daytona 500 2012Detail perlombaan[1] Lomba ke-1 dari 36 dalam Seri Piala musim 2012 Tanggal 28 Februari 2012 (2012-02-28)Lokasi Daytona International SpeedwaySirkuit Fasilitas balap permanen2.5 mil (4.02336 km)Jarak tempuh 200 putaran, 500 mil (804.672 km)Cuaca Mostly cloudy, isolated showersPosisi polePembalap Carl Edwards Roush Fenway RacingWaktu 46.22Terbanyak memimpinPembalap Denny Hamlin Joe Gibbs RacingJumlah putaran 57PemenangNo. 17 Matt Kenseth Roush Fenway RacingTelevisi...

 

Химическая физика

Не следует путать с физической химией. У этого термина существуют и другие значения, см. Химическая физика (значения). Эта статья или раздел нуждается в переработке.Пожалуйста, улучшите статью в соответствии с правилами написания статей. Хими́ческая фи́зика — наука о �...

 

NuStar Energy

U.S. energy company NuStar Energy L.P.Company typePublicTraded asNYSE: NSIndustryOil and Gasoline, TransportationFoundedApril 16, 2001HeadquartersSan Antonio, TexasUnited StatesKey peopleBrad Barron (President & CEO)Tom Shoaf (CFO)[1]ProductsPetrochemicalRevenue $1.9 billion USD (2018)Websitewww.nustarenergy.com NuStar Energy L.P. is a publicly traded master limited partnership. The company is one of the largest independent liquids terminal and pipeline operators in the natio...

2006 Tallahassee mayoral election

2006 Tallahassee mayoral election ← 2003 September 5, 2006 2010 → Turnout35.6%   Nominee John Marks Kim O'Connor Larry Hendricks Party Nonpartisan Nonpartisan Nonpartisan Popular vote 22,894 4,099 2,516 Percentage 77.58% 13.89% 8.53% Mayor before election John Marks Nonpartisan Elected Mayor John Marks Nonpartisan Elections in Florida Federal government Presidential elections 1848 1852 1856 1860 1868 1872 1876 1880 1884 1888 1892 1896 1900 1904 1908 1912 1916 ...

 

Mabel's Strange Predicament

Mabel's Strange PredicamentMabel Normand dalam sebuah adegan dari film tersebutSutradaraMabel NormandProduserMack SennettDitulis olehHenry LehrmanPemeran Mabel Normand Charles Chaplin Chester Conklin Alice Davenport Harry McCoy Hank Mann Al St. John SinematograferH.F. Koenekamp[1]DistributorKeystone StudiosTanggal rilis 09 Februari 1914 (1914-02-09) Durasi17 menitNegaraAmerika SerikatBahasaAntarjudul Inggris Mabel's Strange Predicament Charles Chaplin sebagai Tramp Mabel's Strang...

 

B

  此條目介紹的是拉丁字母中的第2个字母。关于其他用法，请见「B (消歧义)」。   提示：此条目页的主题不是希腊字母Β、西里尔字母В、Б、Ъ、Ь或德语字母ẞ、ß。 BB b(见下)用法書寫系統拉丁字母英文字母ISO基本拉丁字母（英语：ISO basic Latin alphabet）类型全音素文字相关所属語言拉丁语读音方法 [b][p][ɓ](适应变体)Unicode编码U+0042, U+0062字母顺位2数值 2歷史發...

Park Gyeong-ree

Ini adalah nama Korea; marganya adalah Park. Park Gyeong-ree박경리Informasi latar belakangNama lahirPark Gyeong-reeLahir5 Juli 1990 (umur 33)Busan, Korea SelatanGenreK-popPekerjaanPenyanyi, penari, pemeran, peraga busanaInstrumenVokalTahun aktif2012-sekarangLabelStar Empire EntertainmentArtis terkaitNine Muses Templat:Korean membutuhkan parameter |hangul=. Park Gyeong-ree (Hangul: 박경리; lahir 5 Juli 1990), yang lebih dikenal dengan nama panggungnya Gyeongree, ad...

 

Rive Gauche

Part of Paris, France, delimited by the Seine river The arrondissements of Paris with the river Seine bisecting the city. The Rive Gauche is the southern part. The Rive Gauche (French pronunciation: [ʁiv ɡoʃ]; Left Bank) is the southern bank of the river Seine in Paris. Here the river flows roughly westward, cutting the city in two parts. When facing downstream, the southern bank is to the left, whereas the northern bank (or Rive Droite) is to the right. The Rive Gauche is associat...

 

Niccolò Lapiccola

Cet article est une ébauche concernant un peintre italien. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Niccolò LapiccolaNaissance 7 février 1727CrotoneDécès 1790 ou 3 février 1790RomeActivité PeintreLieu de travail Romemodifier - modifier le code - modifier Wikidata Niccolò Lapiccola (Crotone, 7 février 1727 - Rome, 3 février 1790) est un peintre italien baroque de l'école romaine actif au XVIIIe&...

'Abdu'l-Bahá

ʻAbdu'l-Bahá Informasi pribadiLahir`Abbás23 Mei 1844Teheran, PersiaMeninggal28 November 1921(1921-11-28) (umur 77)Haifa, PalestinaMakamKuil `Abdu'l-Bahá32°48′52.59″N 34°59′14.17″E / 32.8146083°N 34.9872694°E / 32.8146083; 34.9872694Koordinat: 32°48′52.59″N 34°59′14.17″E / 32.8146083°N 34.9872694°E / 32.8146083; 34.9872694AgamaBaha'iKebangsaanPersiaPasanganMunírih Khánum ​(m. 1873)​A...

 

Geoff Stults

Geoff Stults nel 2018 Geoffrey Manton Stults (Detroit, 15 dicembre 1977) è un attore ed ex giocatore di football americano statunitense. Indice 1 Biografia 2 Football americano 3 Filmografia parziale 3.1 Cinema 3.2 Televisione 4 Doppiatori italiani 5 Altri progetti 6 Collegamenti esterni Biografia Cresciuto in Colorado, si trasferisce a Los Angeles e comincia a recitare a teatro mentre studia allo Whittier College. Giocatore di football professionista, ha giocato come ricevitore nei Klostern...

 

Procès Milch

Pour les articles homonymes, voir Milch. Cet article est une ébauche concernant la Seconde Guerre mondiale. Vous pouvez partager vos connaissances en l’améliorant (comment ?) selon les recommandations des projets correspondants. Erhard Milch (à gauche) dans un parloir de la prison de Nuremberg. Le procès Milch (officiellement The United States of America vs. Erhard Milch) est le deuxième des douze procès pour crimes de guerre organisé par les autorités américaines dans leur z...

Taiwan Sugar Railways

This article possibly contains original research. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research should be removed. (February 2019) (Learn how and when to remove this message) A Sugar Railway DIEMA diesel locomotive on the Magongcuo LineOverviewMain region(s)TaiwanParent companyTaiwan Sugar CorporationDates of operation1907 (1907)–presentTechnicalTrack gauge762 mm (2 ft 6 in) Taiwan Sug...

 

Diuretic

Substance that promotes the production of urine DiureticsDrug classFurosemide 125 mg vials for intravenous applicationClass identifiersUseForced diuresis, hypertensionATC codeC03External linksMeSHD004232Legal statusIn Wikidata A diuretic (/ˌdaɪjʊˈrɛtɪk/) is any substance that promotes diuresis, the increased production of urine. This includes forced diuresis. A diuretic tablet is sometimes colloquially called a water tablet. There are several categories of diuretics. All diuretics ...

 

القيادة العامة لطيران الأمن (السعودية)

طيران الأمن طيران الأمن—طيران الأمن   تفاصيل الوكالة الحكومية البلد السعودية  الاسم الكامل القيادة العامة لطيران الأمن تأسست 1395 هـ المركز الرياض،  السعودية الإدارة المدير التنفيذي عبد العزيز بن محمد الهويريني الدائرة رئاسة أمن الدولة تعديل مصدري - تعديل   القي...

The Homecoming

1964 theatre play by Harold Pinter For other uses, see The Homecoming (disambiguation). The HomecomingFirst edition (publ. Methuen & Co. Ltd.)Written byHarold PinterCharactersMax Lenny Sam Joey Teddy RuthDate premiered3 June 1965Place premieredAldwych Theatre, LondonOriginal languageEnglishSubjectFamilyGenreDramaSettingSummer. An old house in North London.Official site Carolyn Jones and John Church were replacements in the original Broadway production, as Ruth and Lenny (1967)[1] ...

 

Bulahdelah, New South Wales

Town in New South Wales, AustraliaBulahdelahNew South WalesBulahdelah seen from nearby hillsBulahdelahCoordinates32°22′59″S 152°11′43″E / 32.38306°S 152.19528°E / -32.38306; 152.19528Population1,424 (2011 census)[1] • Density5.6/km2 (15/sq mi)Postcode(s)2423Elevation13 m (43 ft)Area270.6 km2 (104.5 sq mi)[1]Time zoneAEST (UTC+10) • Summer (DST)AEDT (UTC+11)Location 235 km (146 ...

 

Brazil–Trinidad and Tobago relations

Bilateral relationsBrazil-Trinidad and Tobago relations Brazil Trinidad and Tobago Brazil–Trinidad and Tobago relations are bilateral relations between Brazil and Trinidad and Tobago. Trinidad and Tobago has an embassy in Brasília[1] and Brazil has an embassy in Port of Spain.[2] History In 1942, a Vice Consulate was created as the first step towards Brazilian-Trinidadian relations. In 1965, The Embassy of Brazil in Port of Spain was created, establishing official relations...

Engineering drawing abbreviations and symbols

Abbreviations and symbols used in engineering drawing Engineering drawing abbreviations and symbols are used to communicate and detail the characteristics of an engineering drawing. This list includes abbreviations common to the vocabulary of people who work with engineering drawings in the manufacture and inspection of parts and assemblies. Technical standards exist to provide glossaries of abbreviations, acronyms, and symbols that may be found on engineering drawings. Many corporations have...

 

Giovan Carlo Iozzelli

Questa voce o sezione sull'argomento politici italiani non cita le fonti necessarie o quelle presenti sono insufficienti. Puoi migliorare questa voce aggiungendo citazioni da fonti attendibili secondo le linee guida sull'uso delle fonti. Segui i suggerimenti del progetto di riferimento. Giovan Carlo Iozzelli Deputato della Repubblica ItalianaLegislaturaVII GruppoparlamentareDemocrazia Cristiana CircoscrizioneFirenze-Pistoia Incarichi parlamentari Componente della VI Commissione (Fi...