Pernell may refer to:

• Pernell (healer) (fl. 1350), English healer
• Pernell Cooper (1963–2016), American Paralympic powerlifter
• Pernell Davis (born 1976), American football defensive tackle
• Pernell McPhee (born 1988), American football linebacker
• Pernell Roberts (1928–2010), American stage, movie and television actor
• Pernell Saturnino, Grammy Award-winner percussionist from Curaçao
• Pernell Schultz (born 1994), Guyanese footballer
• Pernell Whitaker (1964–2019), American boxer and trainer

• Geoffrey Pernell, British soldier, rapist and murderer, along with two other soldiers, of Louise Jensen in 1994 in Cyprus
• LeRoy Pernell, American law professor and former dean
• Lia Pernell (born 1981), American rower
• Ruby Pernell (1917–2001), professor of social work at the University of Minnesota

• Pernell, Oklahoma, United States, an unincorporated community

This disambiguation page lists articles associated with the title Pernell.
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