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Peptide 021

Not to be confused with P21.

Peptide 021
Identifiers
  • (3S)-3-acetamido-4-[[2-[[2-[[(2S)-1-[[(5S,7R)-3-carbamoyl-1-adamantyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-oxobutanoic acid
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC27H42N6O8
Molar mass578.667 g·mol−1
3D model (JSmol)
  • CC(C)C[C@@H](C(=O)NC12C[C@@H]3C[C@H](C1)CC(C3)(C2)C(=O)N)NC(=O)CNC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)C
  • InChI=1S/C27H42N6O8/c1-14(2)4-18(24(40)33-27-9-16-5-17(10-27)8-26(7-16,13-27)25(28)41)32-21(36)12-29-20(35)11-30-23(39)19(6-22(37)38)31-15(3)34/h14,16-19H,4-13H2,1-3H3,(H2,28,41)(H,29,35)(H,30,39)(H,31,34)(H,32,36)(H,33,40)(H,37,38)/t16-,17+,18-,19-,26?,27?/m0/s1
  • Key:LUJZBZPLIRWWGJ-NBONATBJSA-N

Peptide 021 (Ac-DGGLAG-NH2, P021, GLXC-21260) is a synthetic peptide derivative that is derived from a 4-amino acid active fragment of ciliary neurotrophic factor, which has been substituted with an unnatural adamantane based amino acid residue on the end of the chain. This substitution is highly lipophilic and facilitates transport of the molecule across the blood-brain barrier. It has neurotrophic effects and enhances neurogenesis, and has been investigated for treatment of neurological disorders such as Alzheimer's disease.[1][2][3][4][5][6][7]

See also

References

  1. ^ Li B, Wanka L, Blanchard J, Liu F, Chohan MO, Iqbal K, et al. (August 2010). "Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice". FEBS Letters. 584 (15): 3359–3365. Bibcode:2010FEBSL.584.3359L. doi:10.1016/j.febslet.2010.06.025. PMID 20600002.
  2. ^ Bolognin S, Buffelli M, Puoliväli J, Iqbal K (September 2014). "Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound". Neurobiology of Aging. 35 (9): 2134–2146. doi:10.1016/j.neurobiolaging.2014.02.017. PMID 24702821.
  3. ^ Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, et al. (November 2014). "Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease". Neurobiology of Disease. 71: 110–130. doi:10.1016/j.nbd.2014.07.001. PMID 25046994.
  4. ^ Kazim SF, Blanchard J, Bianchi R, Iqbal K (April 2017). "Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome". Scientific Reports. 7 45561. Bibcode:2017NatSR...745561K. doi:10.1038/srep45561. PMC 5377379. PMID 28368015.
  5. ^ Baazaoui N, Iqbal K (June 2017). "Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound". Alzheimer's Research & Therapy. 9 (1) 45. doi:10.1186/s13195-017-0273-7. PMC 5488423. PMID 28655344.
  6. ^ Wei W, Liu Y, Dai CL, Baazaoui N, Tung YC, Liu F, et al. (2021). "Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction". Journal of Alzheimer's Disease. 82 (2): 631–646. doi:10.3233/JAD-201599. PMC 8385525. PMID 34057082.
  7. ^ Lozupone M, Dibello V, Sardone R, Castellana F, Zupo R, Lampignano L, et al. (May 2023). "The development of peptide- and oligonucleotide-based drugs to prevent the formation of abnormal tau in tauopathies". Expert Opinion on Drug Discovery. 18 (5): 515–526. doi:10.1080/17460441.2023.2200245. PMID 37042028.

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